Multiple early factors anticipate post-acute COVID-19 sequelae

Su, Yapeng; Yuan, Dan; Chen, Daniel; H. Ng, Rachel; Wang, Kai; Choi, Jongchan; Li, Sarah; Hong, Sunga; Zhang, Rongyu; Xie, Jingyi; A. Kornilov, Sergey; Scherler, Kelsey; Jimena Pavlovitch-Bedzyk, Ana; Dong, Shen; Lausted, Christopher; Lee, Inyoul; Fallen, Shannon; L. Dai, Chengzhen; Baloni, Priyanka; Smith, Brett; R. Duvvuri, Venkata; G. Anderson, Kristin; Li, Jing; Yang, Fan; J. Duncombe, Caroline; J. McCulloch, Denise; Rostomily, Clifford; Troisch, Pamela; Zhou, Jing; Mackay, Sean; DeGottardi, Quinn; May, Damon; Taniguchi, Ruth; Gittelman, Rachel; Klinger, Mark; M. Snyder, Thomas; Roper, Ryan; Wojciechowska, Gladys; M. Murray, Kim; Edmark, Rick; Evans, Simon; Jones, Lesley; Zhou, Yong; Rowen, Lee; Liu, Rachel; Chour, William; A. Algren, Heather; R. Berrington, William; A. Wallick, Julie; A. Cochran, Rebecca; Micikas, Mary; Wrin, Terri; J. Petropoulos, Christos; Cole, Hunter; Fischer, Trevan; Wei, Wei; S.�B. Hoon, Dave; D. Price, Nathan; Subramanian, Naeha; A. Hill, Joshua; Hadlock, Jennifer; T. Magis, Andrew; Ribas, Antoni; L. Lanier, Lewis; D. Boyd, Scott; A. Bluestone, Jeffrey; Y. Chu, Helen; Hood, Leroy; Gottardo, Raphaël; D. Greenberg, Philip; M. Davis, Mark; D. Goldman, Jason; R. Heath, James

doi:10.1016/j.cell.2022.01.014

Public

Multiple early factors anticipate post-acute COVID-19 sequelae

Published in Cell • Jan 25, 2022

Authors:

Yapeng Su

Dan Yuan

Daniel Chen

Abstract

T cells exhibited unique dynamics during recovery from COVID-19. Analysis of symptom-associated immunological signatures revealed coordinated immunity polarization into four endotypes, exhibiting divergent acute severity and PASC. We find that immunological associations between PASC factors diminish...

Subject

Convalescence

Biology

Coronavirus disease 2019 (COVID-19)

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