Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19

D. Perkins, Gavin; Ji, Chen; Connolly, Bronwen; Couper, Keith; Lall, Ranjit; Kenneth Baillie, J.; Bradley, Judy; Dark, Paul; Dave, Chirag; De Soyza, Anthony; Dennis, Anna; Devrell, Anne; Fairbairn, Sara; Ghani, Hakim; Gorman, Ellen; Green, Christopher; Hart, Nicholas; Wan Hee, Siew; Kimbley, Zoe; Madathil, Shyam; McGowan, Nicola; Messer, Benjamin; Naisbitt, Jay; Norman, Chloe; Parekh, Dhruv; M Parkin, Emma; Patel, Jaimin; Regan, Scott; Ross, Clare; Rostron, Anthony; Saim, Mohammad; K. Simonds, Anita; Skilton, Emma; Stallard, Nigel; Steiner, Michael; Vancheeswaran, Rama; Yeung, Joyce; F. McAuley, Daniel; Collaborators, RECOVERY-RS; Duffy, Nick; Kelly, Martin; Concannon, Dónal; M. Ferguson, Kathryn; McClintock, Declan; Jha, Rajeev; Krishnamurthy, Vinodh; O’Farrell, Stephen; O’Kane, Cecilia; Ross, Clare; Turner, Richard; Miodragovic, Serge; C.T. Hawkins, Peter; Welbourne, Jessie; Wells, Colin; Lankester, Liana; D Waddy, Samuel; Lentaigne, Julian; Nesbitt, Jay; Clarke, Sarah; Houghton, Catherine; O’Riordan, Devaki; Shepherd, Kate; Turnpenny, Beth; Joseph, Rosane; Steiner, Michael; Rossall, Clare; Mundin, Rachel; Boschi, Samuele; McAuley, Hamish; Russell, Richard; Diver, Sarah; Elneima, Omer; Ibrahim, Wadah; Yousuf, Ahmed; Edwards, Sarah; Saim, Mohammad; Hopkins, Bridget; M. Kelly, Lisa; Lenton, Daniel; Shackleford, Helen; Thrasyvoulou, Laura; Willis, Heather; Fairbairn, Sara; Green, Chris; Patel, Mamta; Linhartová, Lucie; Hayton, Emma; Chue, Amy; Collins, Ben; Page, Matt; Birkhamshaw, Ed; Bellamy, Mary; Bancroft, Hollie; Gallagher, Emma; Antoine‐Pitterson, Pearlene; Jones, Beth; Begum, Safia; Dhani, Sundip; G. Crooks, Michael; Brindle, Kayleigh; Faruqi, Shoaib; Flockton, Rachel; Pinder, Emma; Thackray-Nocera, Susannah; Dalemo, Keji; Doidge, James; Edwards, Julia; Douse, J; Bell, Stephanie; Purewal, Bally; Chabo, Cathleen; Buckman, Carol; Beeby, Deborah; Gray, Georgina; Francis, Rebecca; Rivers, Vanessa; Burton, Matthew; Innes, Nicholas; Ghattas, Sandy; Rabbani, Rana; Mahadevan, Venkat; Mahadevan, Venkateswaran; Green, Alastair; Burton, Ben; Hacon, Christian; Wilhelmsen, Elva; R Hughes, Paul; Lee, Kai; Lowsby, Richard; H. Baker, Laurence; Board, Perry; Chauhan, Varun; Clarke, Sheron; Fullerton, Duncan; Gabriel, Claire; Houston, Tom; Lees, Diana; Normanton, Robert; Pagett, Katherine; Thornley, Sarah; T. Wright, H.; McMillan, Alison; Babores, Marta; Lee, Xiang; Nagarajan, Thapas; Holland, Maureen; Sanctuary, Thomas; Innes, Richard; Fletcher, Simon; Sehgal, Nita; Duncan, Tracy; Pooley, Justine; Watkins, Emma; Moudgil, Harmesh; Carnahan, Mandy; Donaldson, Denise; Rao, Deepak; Tey, C; Linkson, L; Buttle, Tom; Vidler, Jennifer; Griffiths, Nicola; Hicks, Alexander; Rupani, Hitasha; Alfridi, Afaq; Barns, Debi; Cowan, Elena; David, Mini; Darbyshire, Alex; Giles, Ben; Roberts, Claire; Lameirinhas, Claudia; Neville, Daniel; Hossain, Ejaz; Thompson, Fiona; Edwards, Helena; Naftel, Jen; Winter, Jonathan; Burrows, Kate; Wiffen, Laura; Fox, Lauren; Murray, Lisa; Hawes, Liz; Mamman, Madhu; Moon, Maria; White, Marie; Rowley, Megan; Szarazova, Nina; Gosling, Sally; Cooper, Simon; Baryschpolec, Sonia; Arndtz, Sophie; H-Davies, Yasmin; Abed El Khaleq, Yazeed; Garner, Zoe; Vythilingam, Siyamini; Yang, Yingjja; Parekh, Dhruv; Madathil, Shyam; Patel, Jaimin; Bergin, Colin; Bates, Michelle; McGhee, Christopher; Lynch, Daniella; Bhandal, Khushpreet; Tsakiridou, Kyriaki; Bamford, Amy; B. Cooper, Lauren; Whitehouse, Tony; Veenith, Tonny; Forster, Elliott; Lane, Steph; Adams, Nick; MacDonald, S.M.; Manan, Sana; T. Lugg, Sebastian; A Shah, Peer; McKemey, Emily; Crowley, Louise; Mussawar, G.; Gogokhia, Atena; Gompertz, Simon; Snelson, Catherine; Oelofse, Tessa; Wilson, Jeremy; N. Bangash, Mansoor; Huq, Syed; Rauf, Farrukh; Dosanjh, Davinder; Salmon, Natasha; Tengende, Joyce; F Senior, Kay; Cooper, Brendan; Sutton, Benjamin; Woolhouse, Ian; Crawshaw, Anjali; L. Thompson, Richard; Glynn, Patricia; Naylor, Jon; Alderman, Joseph; Chotalia, Minesh; Le Breuilly, Martin; Talbot, Nicholas; Packer, Greg; Carlin, C; Harvey, Daniel; Gray, Alasdair; Gautam, Manish; Welters, Ingeborg; Hamilton, David; Burhan, Hassan; Hunter, Karl; Johnston, Brian; G. Vega López, María; Lowe, Catherine; Mulla, Suleman; Fernandez Roman, Jaime; Shaw, David; Waite, Alicia; Waugh, Victoria; Williams, Karen; K. Simonds, Anita; Tatham, Kate; Black, Ethel; Jhanji, Shaman; Ng Man Kwong, Georges; Messer, Ben; De Soyza, Anthony; McAlinden, Paul; West, Sophie; Anumakonda, Vikram; Dark, Paul; McMorrow, Liam; Marsden, Tracy; Proudfoot, Nicola; Charles, Bethan; Pendlebury, Jessica; Blackledge, Bethan; Harvey, Alice; Knowles, Karen; Doonan, Reece; J. Lee, Stephanie; Perez, Jane; Slaughter, Melanie; Taylor, Melanie; Thomas, Victoria; Hardy, Emma; Diar Bakerly, Nawar; Catlow, Laura; Majeed, Nasir; Horner, Daniel; Ali, Liaquat; Hutchinson, Dorothy; Fuller, Liz; Dodd, James; Bhatnagar, Rahul; Clive, Amelia; Adamali, Huzaifa; Bibby, Anna; Higbee, Daniel; Welch, H; Gendall, Emma; Staddon, Louise; Morley, Anna; Clarke, Sam; Smith, Kerry; Perry, Emily; Rippon, Naomi; Jennings, Louise; Solomon, Louise; Alloway, Karen; Lee, Hannah; Sandrey, Victoria; Bradburn, Kirstie; Milne, Alice; Goff, Elizabeth; Williams, Rachel; Ahmed, Mohammed; Bloch, Susannah; Zaki, Ahmed; Roy, Alistair; Rostron, Anthony; Woods, Lindsey; Wakinshaw, Fiona; Bainbridge, Pamela; Hersey, Peter; G. Carpenter, Mark; Leech, Claire; O’Connor, Laura; Morrison, Andrew; Rodgers, Elaine; McAndrew, P.; Lear, Gary; Coates, Jim; J. Richardson, Maxwell; M. Smith, David; H. Green, William; M. Murray, Sarah; Pennington, Christopher; De Wong, Huan; Land, David; Wheeler, Helen; Harvey, Matt; Watson, Mark; Brown, Michael; Irving, Ben; Bigg, Julie; Felongco, Mae; Mackenzie, Joe; Dhasmana, Devesh; Thompson, Rob; Lui, Patrick; Adam, Fiona; Davey, Fleur; Penman, Julie; McGregor, Amanda; Cochrane, Patricia; Shalan, Korah; Bozic, Will; Brown, Jaclyn; Carey, John; Daffern, Claire; Dight, Emily; Gane, Matthew; Ghuman, Belinder; Grummett, Jo; Guck, Johnny; Hamilton, Louisa; Hill, Cat; Hill, Maddy; Muthiah, Chockalingam; Padfield, Emma; Rai, Jeskaran; Raynes, Kerry; Scott, Gregory; Stimpson, Emily; R. Strickland, Natalie; Willis, Adrian; Wood, Jill; Attwood, Ben; Atwal, Inderjit; Parsons, Penny; Vancheeswaran, Rama; Konda, Shruthi; Myint, Yadee; Mehta, Meera; Iqbal Muhammad, Ambreen; Navarro, Alessio; Rochester, Adam; Sundayi, Saul; Patel, Manish; Smith, Andrew; J.R. Stewart, Colin; Tate, Matthew; McGarry, Erin; Pearson, Claire; Walsh, Berni; Glass, Lynn; Black, Karen; Clements, Suzanne; Boyle, Rosalind; Macdonald, Chloe; Hamilton, Leigh; Moreland, Gayle; Hamill, Raymond; Reddy, Harsha; Smuts, Sara; Bentley, Andrew

doi:10.1001/jama.2022.0028

Public

Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19

Published in JAMA • Jan 24, 2022

Authors:

Gavin D. Perkins

Chen Ji

Bronwen Connolly

Abstract

Importance: Continuous positive airway pressure (CPAP) and high-flow nasal oxygen (HFNO) have been recommended for acute hypoxemic respiratory failure in patients with COVID-19. Uncertainty exists regarding the effectiveness and safety of these noninvasive respiratory strategies. Objective: To deter...

Subject

Medicine

Oxygen therapy

Intubation

Research Assistant

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