Th17 CD4+ T-Cell as a Preferential Target for HIV Reservoirs

Renault, Constance; Veyrenche, Nicolas; J. D. Mennechet, Franck; Bedin, Anne‐Sophie; Routy, Jean‐Pierre; Van de Perre, Philippe; Reynes, Jacques; Tuaillon, Édouard

doi:10.3389/fimmu.2022.822576

Public

Th17 CD4+ T-Cell as a Preferential Target for HIV Reservoirs

Published in Frontiers in Immunology • Feb 7, 2022

Authors:

Constance Renault

Nicolas Veyrenche

Franck J. D. Mennechet

Abstract

Among CD4+ T-cells, T helper 17 (Th17) cells play a sentinel role in the defense against bacterial/fungal pathogens at mucosal barriers. However, Th17 cells are also highly susceptible to HIV-1 infection and are rapidly depleted from gut mucosal sites, causing an imbalance of the Th17/Treg ratio and...

Subject

Immunology

C-C chemokine receptor type 6

Homing (biology)

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