Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer

Ruiz-Fernández de Córdoba, Borja; Moreno, Haritz; Valencia, Karmele; Perurena, Naiara; Ruedas, Pablo; Walle, Thomas; Pezonaga-Torres, Alberto; Hinojosa, Juan; Guruceaga, Elisabet; Pineda-Lucena, Antonio; Abengózar-Muela, Marta; Cochonneau, Denis; Zandueta, Carolina; Martínez-Canarias, Susana; Teijeira, Álvaro; Ajona, Daniel; Ortiz-Espinosa, Sergio; Morales, Xabier; Ortiz de Solórzano, Carlos; Santisteban, Marta; I. Ramos-García, Luis; Guembe, Laura; Strnad, Vratislav; Heymann, Dominique; Hervás-Stubbs, Sandra; Pío, Rubén; E. Rodríguez-Ruiz, María; E. de Andrea, Carlos; Vicent, Silvestre; Melero, Ignacio; Lecanda, Fernando; Martínez-Monge, Rafael

doi:10.1158/2159-8290.cd-21-0932

Public

Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer

Published in Cancer Discovery • Jan 27, 2022

Authors:

Borja Ruiz-Fernández de Córdoba

Haritz Moreno

Karmele Valencia

Abstract

ABSTRACT: Locoregional failure (LRF) in patients with breast cancer post-surgery and post-irradiation is linked to a dismal prognosis. In a refined new model, we identified ectonucleotide pyrophosphatase/phosphodiesterase 1/CD203a (ENPP1) to be closely associated with LRF. ENPP1hi circulating tumor ...

Subject

Suppressor

Cancer research

Breast cancer

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