The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell–monocyte crosstalk and protects against atherosclerosis via the NF-κB pathway

Maria Farina, Floriana; Serio, Simone; Fernando Hall, Ignacio; Zani, Stefania; Andrea Cassanmagnago, Giada; Climent, Montserrat; Civilini, Efrem; Condorelli, Gianluigi; Quintavalle, Manuela; Elia, Leonardo

doi:10.1093/eurheartj/ehac097

Public

The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell–monocyte crosstalk and protects against atherosclerosis via the NF-κB pathway

Published in European Heart Journal • Feb 18, 2022

Authors:

Floriana Maria Farina

Simone Serio

Ignacio Fernando Hall

Abstract

AIMS: Histone H3 dimethylation at lysine 79 is a key epigenetic mark uniquely induced by methyltransferase disruptor of telomeric silencing 1-like (DOT1L). We aimed to determine whether DOT1L modulates vascular smooth muscle cell (VSMC) phenotype and how it might affect atherosclerosis in vitro and ...

Subject

Epigenetics

Cell biology

Gene silencing

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