The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration

Senage, Thomas; Paul, Anu; Le Tourneau, Thierry; Fellah-Hebia, Imen; Vadori, Marta; Bashir, Salam; Galiñanes, Manuel; Bottio, Tomaso; Gerosa, Gino; Evangelista, Arturo; P. Badano, Luigi; Nassi, Alberto; Costa, Cristina; Cesare, Galli; A. Manji, Rizwan; Cueff de Monchy, Caroline; Piriou, Nicolas; Capoulade, Romain; Serfaty, Jean-Michel; Guimbretière, Guillaume; Dantan, Etienne; Ruiz-Majoral, Alejandro; Coste du Fou, Guénola; Leviatan Ben-Arye, Shani; Govani, Liana; Yehuda, Sharon; Bachar Abramovitch, Shirley; Amon, Ron; Moshe Reuven, Eliran; Atiya-Nasagi, Yafit; Yu, Hai; Iop, Laura; Casós, Kelly; G. Kuguel, Sebastián; Blasco-Lucas, Arnau; Permanyer, Eduard; Sbraga, Fabrizio; Llatjós, Roger; Moreno-Gonzalez, Gabriel; Sánchez-Martínez, Melchor; E. Breimer, Michael; Holgersson, Jan; Teneberg, Susann; Pascual-Gilabert, Marta; Nonell-Canals, Alfons; Takeuchi, Yasuhiro; Chen, Xi; Mañez, Rafael; Roussel, Jean-Christian; Soulillou, Jean-Paul; Cozzi, Emanuele; Padler-Karavani, Vered

doi:10.1038/s41591-022-01682-w

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The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration

Shared by NobleBlocks on Feb 1, 2022 • 12:00 AM UTC

Authors:

Thomas Senage

Anu Paul

Thierry Le Tourneau

Abstract

Abstract Bioprosthetic heart valves (BHVs) are commonly used to replace severely diseased heart valves but their susceptibility to structural valve degeneration (SVD) limits their use in young patients. We hypothesized that antibodies against immunogenic glycans present on BHVs, particularly antibod...

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