Processing and Subcellular Localization of the Hepatitis E Virus Replicase: Identification of Candidate Viral Factories

Metzger, Karoline; Bentaleb, Cyrine; Hervouet, Kévin; Alexandre, Virginie; Montpellier, Claire; Saliou, Jean-Michel; Ferrié, Martin; Camuzet, Charline; Rouillé, Yves; Lecoeur, Cécile; Dubuisson, Jean; Cocquerel, Laurence; Aliouat-Denis, Cécile-Marie

doi:10.3389/fmicb.2022.828636

Public

Processing and Subcellular Localization of the Hepatitis E Virus Replicase: Identification of Candidate Viral Factories

Shared by NobleBlocks on Feb 24, 2022 • 12:00 AM UTC

Authors:

Karoline Metzger

Cyrine Bentaleb

Kévin Hervouet

Abstract

Hepatitis E virus (HEV) is the major cause of acute hepatitis worldwide. HEV is a positive-sense RNA virus expressing three open reading frames (ORFs). ORF1 encodes the ORF1 non–structural polyprotein, the viral replicase which transcribes the full-length genome and a subgenomic RNA that encodes the...

Discussions