Toripalimab plus chemotherapy in treatment-naïve, advanced esophageal squamous cell carcinoma (JUPITER-06): A multi-center phase 3 trial

Wang, Zixian; Cui, Chengxu; Yao, Jun; Zhang, Yanqiao; Li, Mengxia; Feng, Ji‐Feng; Yang, Shujun; Fan, Yun; Shi, Jianhua; Zhang, Xizhi; Shen, Lin; Shu, Yongqian; Wang, Cailian; Dai, Tianyang; Mao, Teng; Chen, Long; Guo, Zengqing; Liu, Bo; Pan, Hongming; Cang, Shundong; Jiang, Yi; Wang, Junye; Ye, Min; Chen, Zhendong; Jiang, Da; Lin, Qin; Ren, Wei; Wang, Junsheng; Wu, Lin; Xu, Yong; Miao, Zhanhui; Sun, Meili; Xie, Conghua; Liu, Ying; Wang, Qifeng; Zhao, Lina; Li, Qi; Huang, Canhong; Jiang, Ke; Yang, Kunyu; Li, Daojun; Liu, Yunpeng; Zhu, Zhitu; Chen, Rixin; Jia, Liqun; Li, Wei; Liao, Wangjun; Liu, Hongxu; Ma, Daiyuan; Ma, Jie; Qin, Yanru; Shi, Zhihong; Wei, Qichun; Xiao, Ke; Zhang, Yan; Zhang, Ying; Chen, Xin; Dai, Guanghai; He, Jianxing; Li, Junhe; Li, Guanghui; Liu, Yong; Liu, Zhihua; Yuan, Xianglin; Zhang, Junping; Fu, Zhichao; He, Yifu; Ju, Fang; Liu, Zheng; Tang, Peng; Wang, Tiejun; Wang, Weibo; Zhang, Jing; Luo, Xianming; Tang, Xiongwen; May, Rena; Feng, Hui; Yao, Sheng; Keegan, Patricia; Xu, Rui‐Hua; Wang, Feng

doi:10.1016/j.ccell.2022.02.007

Public

Toripalimab plus chemotherapy in treatment-naïve, advanced esophageal squamous cell carcinoma (JUPITER-06): A multi-center phase 3 trial

Published in Cancer Cell • Mar 1, 2022

Authors:

Zixian Wang

Chengxu Cui

Jun Yao

Abstract

Platinum-based chemotherapy is the standard first-line treatment for advanced esophageal squamous cell carcinoma (ESCC). In this phase 3 study (ClinicalTrial.gov: NCT03829969), 514 patients with treatment-naïve advanced ESCC were randomized (1:1) to receive toripalimab or placebo in combination with...

Subject

Placebo

Medicine

Internal medicine

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