8-oxoguanine and 8-oxodeoxyguanosine Biomarkers of Oxidative DNA Damage: A Review on HPLC–ECD Determination

Chiorcea‐Paquim, Ana‐Maria

doi:10.3390/molecules27051620

Public

8-oxoguanine and 8-oxodeoxyguanosine Biomarkers of Oxidative DNA Damage: A Review on HPLC–ECD Determination

Published in Molecules • Mar 1, 2022

Authors:

Ana‐Maria Chiorcea‐Paquim

Abstract

Reactive oxygen species (ROS) are continuously produced in living cells due to metabolic and biochemical reactions and due to exposure to physical, chemical and biological agents. Excessive ROS cause oxidative stress and lead to oxidative DNA damage. Within ROS-mediated DNA lesions, 8-oxoguanine (8-...

Subject

Oxidative stress

Deoxyguanosine

8-Hydroxy-2'-deoxyguanosine

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