Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

Cele, Sandile; Jackson, Laurelle; S. Khoury, David; Khan, Khadija; Moyo-Gwete, Thandeka; Tegally, Houriiyah; Emmanuel San, James; Cromer, Deborah; Scheepers, Cathrine; G. Amoako, Daniel; Karim, Farina; Bernstein, Mallory; Lustig, Gila; Archary, Derseree; Smith, Muneerah; Ganga, Yashica; Jule, Zesuliwe; Reedoy, Kajal; Hwa, Shi-Hsia; Giandhari, Jennifer; M. Blackburn, Jonathan; I. Gosnell, Bernadett; S. Abdool Karim, Salim; Hanekom, Willem; , NGS-SA; Davies, Mary-Ann; Hsiao, Marvin; Martin, Darren; Mlisana, Koleka; Kurt Wibmer, Constantinos; Williamson, Carolyn; York, Denis; Team, COMMIT-KZN; Harrichandparsad, Rohen; Herbst, Kobus; Jeena, Prakash; Khoza, Thandeka; Kløverpris, Henrik; Leslie, Alasdair; Madansein, Rajhmun; Magula, Nombulelo; Manickchund, Nithendra; Marakalala, Mohlopheni; Mazibuko, Matilda; Moshabela, Mosa; Mthabela, Ntombifuthi; Naidoo, Kogie; Ndhlovu, Zaza; Ndung’u, Thumbi; Ngcobo, Nokuthula; Nyamande, Kennedy; Patel, Vinod; Smit, Theresa; Steyn, Adrie; Wong, Emily; von Gottberg, Anne; N. Bhiman, Jinal; J. Lessells, Richard; S. Moosa, Mahomed-Yunus; P. Davenport, Miles; de Oliveira, Tulio; L. Moore, Penny; Sigal, Alex

doi:10.1038/s41586-021-04387-1

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Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

Shared by NobleBlocks on Dec 23, 2021 • 12:00 AM UTC

Authors:

Sandile Cele

Laurelle Jackson

David S. Khoury

Abstract

Abstract The emergence of the SARS-CoV-2 variant of concern Omicron (Pango lineage B.1.1.529), first identified in Botswana and South Africa, may compromise vaccine effectiveness and lead to re-infections 1 . Here we investigated Omicron escape from neutralization by antibodies from South African in...

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