Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

Cele, Sandile; Jackson, Laurelle; S. Khoury, David; Khan, Khadija; Moyo-Gwete, Thandeka; Tegally, Houriiyah; Emmanuel San, James; Cromer, Deborah; Scheepers, Cathrine; G. Amoako, Daniel; Karim, Farina; Bernstein, Mallory; Lustig, Gila; Archary, Derseree; Smith, Muneerah; Ganga, Yashica; Jule, Zesuliwe; Reedoy, Kajal; Hwa, Shi-Hsia; Giandhari, Jennifer; M. Blackburn, Jonathan; I. Gosnell, Bernadett; S. Abdool Karim, Salim; A. Hanekom, Willem; , NGS-SA; Davies, Mary‐Ann; Hsiao, Marvin; P. Martin, Darren; Mlisana, Koleka; Kurt Wibmer, Constantinos; Williamson, Carolyn; York, Denis; Team, COMMIT-KZN; Harrichandparsad, Rohen; Herbst, Kobus; Jeena, Prakash; Khoza, Thandeka; N. Kløverpris, Henrik; Leslie, Alasdair; Madansein, Rajhmun; Magula, Nombulelo; Manickchund, Nithendra; J. Marakalala, Mohlopheni; Mazibuko, Matilda; Moshabela, Mosa; Mthabela, Ntombifuthi; Naidoo, Kogie; M. Ndhlovu, Zaza; Ndung’u, Thumbi; Ngcobo, Nokuthula; Nyamande, Kennedy; Patel, Vinod; Smit, Theresa; J. C. Steyn, Adrie; Wong, Emily; von Gottberg, Anne; N. Bhiman, Jinal; Lessells, Richard; S. Moosa, Mahomed‐Yunus; P. Davenport, Miles; de Oliveira, Túlio; L. Moore, Penny; Sigal, Alex

doi:10.1038/s41586-021-04387-1

Public

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

Published in Nature • Dec 23, 2021

Authors:

Sandile Cele

Laurelle Jackson

David S. Khoury

Abstract

. Here we investigated Omicron escape from neutralization by antibodies from South African individuals vaccinated with Pfizer BNT162b2. We used blood samples taken soon after vaccination from individuals who were vaccinated and previously infected with SARS-CoV-2 or vaccinated with no evidence of pr...

Subject

Neutralization

Chemistry

Computational biology

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