Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

Okbay, Aysu; Wu, Yeda; Wang, Nancy; Jayashankar, Hariharan; Bennett, Michael; Moeen Nehzati, Seyed; Sidorenko, Julia; Kweon, Hyeokmoon; Goldman, Grant; Gjorgjieva, Tamara; Jiang, Yunxuan; Hicks, Barry; Tian, Chao; A. Hinds, David; Ahlskog, Rafael; K. E. Magnusson, Patrik; Oskarsson, Sven; Hayward, Caroline; Campbell, Archie; J. Porteous, David; Freese, Jeremy; Herd, Pamela; Agee, Michelle; Alipanahi, Babak; Auton, Adam; K. Bell, Robert; Bryc, Katarzyna; L. Elson, Sarah; Fontanillas, Pierre; A. Furlotte, Nicholas; A. Hinds, David; E. Huber, Karen; Kleinman, Aaron; K. Litterman, Nadia; C. McCreight, Jennifer; H. McIntyre, Matthew; L. Mountain, Joanna; A. M. Northover, Carrie; J. Pitts, Steven; Fah Sathirapongsasuti, J.; V. Sazonova, Olga; F. Shelton, Janie; Shringarpure, Suyash; Y. Tung, Joyce; Vacic, Vladimir; H. Wilson, Catherine; Alan Fontana, Mark; H. Pers, Tune; A. Rietveld, Cornelius; Chen, Guo‐Bo; Emilsson, Valur; Fleur W. Meddens, S.; K. Pickrell, Joseph; Thom, Kevin; Timshel, Pascal; de Vlaming, Ronald; Abdellaoui, Abdel; S. Ahluwalia, Tarunveer; Bačelis, Jonas; Baumbach, Clemens; Björnsdóttir, Gyða; Brandsma, J; Pina Concas, Maria; Derringer, Jaime; E. Galesloot, Tessel; Girotto, Giorgia; Gupta, Richa; M. Hall, Leanne; E. Harris, Sarah; Hofer, Edith; Horikoshi, Momoko; E. Huffman, Jennifer; Kaasik, Kadri; Panagiota Kalafati, Ioanna; Karlsson, Robert; Lahti, Jari; J. van der Lee, Sven; de Leeuw, Christiaan; A. Lind, Penelope; Lindgren, Karl‐Oskar; Liu, Tian; Mangino, Massimo; Marten, Jonathan; Mihailov, Evelin; Miller, Michael; J. van der Most, Peter; Oldmeadow, Christopher; Payton, Antony; Pervjakova, Natalia; J. Peyrot, Wouter; Qian, Yong; T. Raitakari, Olli; Rueedi, Rico; Salvi, Erika; Schmidt, Börge; E. Schraut, Katharina; Shi, Jianxin; V. Smith, Albert; A. Poot, Raymond; St Pourcain, Beaté; Teumer, Alexander; Þorleifsson, Guðmar; Verweij, Niek; Vuckovic, Dragana; Wellmann, Juergen; Westra, Harm-Jan; Yang, Jingyun; Zhao, Wei; Zhu, Zhihong; Z. Alizadeh, Behrooz; Amin, Najaf; Bakshi, Andrew; E. Baumeister, Sebastian; Biino, Ginevra; Bønnelykke, Klaus; A. Boyle, Patricia; Campbell, Harry; P. Cappuccio, Francesco; Davies, Gail; De Neve, Jan-Emmanuel; Deloukas, Panos; Demuth, Ilja; Ding, Jun; Eibich, Peter; Eisele, Lewin; Eklund, Niina; M. Evans, David; D. Faul, Jessica; F. Feitosa, Mary; J. Forstner, Andreas; Gandin, Ilaria; Gunnarsson, Bjarni; V. Halldórsson, Bjarni; B. Harris, Tamara; C. Heath, Andrew; J. Hocking, Lynne; G. Holliday, Elizabeth; Homuth, Georg; A. Horan, Michael; Hottenga, Jouke‐Jan; L. De Jager, Philip; K. Joshi, Peter; Jugessur, Astanand; Kaakinen, Marika; Kähönen, Mika; Kanoni, Stavroula; Keltigangas-Järvinen, Liisa; A. Kiemeney, Lambertus; Kolčić, Ivana; Koskinen, Seppo; T. Kraja, Aldi; Kroh, Martin; Kutalik, Zoltán; Latvala, Antti; J. Launer, Lenore; P. Lebreton, Maël; F. Levinson, Douglas; Lichtenstein, Paul; Lichtner, Peter; C. Liewald, David; Cohort Study, LifeLines; Loukola, Anu; A. F. Madden, Pamela; Mägi, Reedik; Mäki‐Opas, Tomi; E. Marioni, Riccardo; Marques‐Vidal, Pedro; A. Meddens, Gerardus; McMahon, George; Meisinger, Christa; Meitinger, Thomas; Milaneschi, Yusplitri; Milani, Lili; W. Montgomery, Grant; Myhre, Ronny; P. Nelson, Christopher; R. Nyholt, Dale; Ollier, William; Palotie, Aarno; Paternoster, Lavinia; L. Pedersen, Nancy; Petrovic, Katja; Räikkönen, Katri; M. Ring, Susan; Robino, Antonietta; Rostapshova, Olga; Rudan, Igor; Rustichini, Aldo; Salomaa, Veikko; R. Sanders, Alan; Sarin, Antti‐Pekka; Schmidt, Helena; J. Scott, Rodney; H. Smith, Blair; A. Smith, Jennifer; A. Staessen, Jan; Steinhagen–Thiessen, Elisabeth; Strauch, Konstantin; Terracciano, Antonio; D. Tobin, Martin; Ulivi, Sheila; Vaccargiu, Simona; Quaye, Lydia; J.A. van Rooij, Frank; Venturini, Cristina; A. E. Vinkhuyzen, Anna; Völker, Uwe; Völzke, Henry; M. Vonk, Judith; Vozzi, Diego; Waage, Johannes; B. Ware, Erin; Willemsen, Gonneke; Attia, John; A. Bennett, David; Berger, Klaus; Bertram, Lars; Bisgaard, Hans; I. Boomsma, Dorret; B. Borecki, Ingrid; Bültmann, Ute; F. Chabris, Christopher; Cucca, Francesco; Cusi, Daniele; J. Deary, Ian; Dedoussis, George; M. van Duijn, Cornelia; G. Eriksson, Johan; Franke, Barbara; Franke, Lude; Gasparini, Paolo; V. Gejman, Pablo; Gieger, Christian; J. Grabe, Hans; Gratten, Jacob; J. F. Groenen, Patrick; Guðnason, Vilmundur; van der Harst, Pim; Hoffmann, Wolfgang; Hyppönen, Elina; G. Iacono, William; Jacobsson, Bo; Järvelin, Marjo‐Riitta; Jöckel, Karl‐Heinz; Kaprio, Jaakko; L. R. Kardia, Sharon; Lehtimäki, Terho; F. Lehrer, Steven; G. Martin, Nicholas; McGue, Matt; Metspalu, Andres; Pendleton, Neil; W.J.H. 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doi:10.1038/s41588-022-01016-z

Public

Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

Published in Nature Genetics • Mar 31, 2022

Authors:

Aysu Okbay

Yeda Wu

Nancy Wang

Abstract

We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 1...

Subject

Genome-wide association study

Biology

Single-nucleotide polymorphism

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