PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis

Jiang, Wenhao; Jin, Yunyun; Zhang, Shiwei; Ding, Yi; Huo, Konglin; Yang, Junjie; Жао, Леи; Nian, Baoning; P. Zhong, Tao; Lü, Weiqiang; Zhang, Hankun; Cao, Xu; M. Shah, Karan; Wang, Ning; Liu, Mingyao; Luo, Jian

doi:10.1038/s41413-022-00201-4

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PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis

Published in Bone Research • Mar 9, 2022

Authors:

Wenhao Jiang

Yunyun Jin

Shiwei Zhang

Abstract

Abstract Prostaglandin E2 (PGE2), a major cyclooxygenase-2 (COX-2) product, is highly secreted by the osteoblast lineage in the subchondral bone tissue of osteoarthritis (OA) patients. However, NSAIDs, including COX-2 inhibitors, have severe side effects during OA treatment. Therefore, the identific...

Subject

Osteoarthritis

Prostaglandin E2 receptor

Prostaglandin E2

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