Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity

Cabral-Marques, Otávio; Halpert, Gilad; F. Schimke, Lena; Ostrinski, Yuri; Vojdani, Aristo; Baiocchi, G.; Paccielli Freire, Paula; Salerno Filgueiras, Igor; Zyskind, Israel; T. Lattin, Miriam; Tran, Florian; Schreiber, Stefan; H. C. Marques, Alexandre; Rodrigues Plaça, Desirée; Leandro M. Fonseca, Dennyson; Y. Humrich, Jens; Müller, Antje; M. Giil, Lasse; Graßhoff, Hanna; Schümann, Anja; Hackel, Alexander; Junker, Juliane; Meyer, Carlotta; D. Ochs, Hans; Lavi, Yael; Scheibenbogen, Carmen; Dechend, Ralf; Jurišica, Igor; Schulze‐Forster, Kai; I. Silverberg, Jonathan; Amital, Howard; Zimmerman, Jason; Heidecke, Harry; Z. Rosenberg, Avi; Riemekasten, Gabriela; Shoenfeld, Yehuda

doi:10.1038/s41467-022-28905-5

Public

Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity

Published in Nature Communications • Mar 9, 2022

Authors:

Otávio Cabral-Marques

Gilad Halpert

Lena F. Schimke

Abstract

COVID-19 shares the feature of autoantibody production with systemic autoimmune diseases. In order to understand the role of these immune globulins in the pathogenesis of the disease, it is important to explore the autoantibody spectra. Here we show, by a cross-sectional study of 246 individuals, th...

Subject

Autoantibody

Immunology

Antibody

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