ChAdOx1‐S adenoviral vector vaccine applied intranasally elicits superior mucosal immunity compared to the intramuscular route of vaccination

Cokarić Brdovčak, Maja; Materljan, Jelena; Šustić, Marko; Ravlić, Sanda; Ružić, Tina; Lisnić, Berislav; Miklić, Karmela; Brizić, Ilija; Pribanić Matešić, Marina; Juranić Lisnić, Vanda; Halassy, Beata; Rončević, Dobrica; Knežević, Zdravka; Štefan, Leo; Bertoglio, Federico; Schubert, Maren; Čičin‐Šain, Luka; Markotić, Alemka; Jonjić, Stipan; Krmpotić, Astrid

doi:10.1002/eji.202249823

Public

ChAdOx1‐S adenoviral vector vaccine applied intranasally elicits superior mucosal immunity compared to the intramuscular route of vaccination

Published in European Journal of Immunology • Mar 19, 2022

Authors:

Maja Cokarić Brdovčak

Jelena Materljan

Marko Šustić

Abstract

COVID-19 vaccines prevent severe forms of the disease, but do not warrant complete protection against breakthrough infections. This could be due to suboptimal mucosal immunity at the site of virus entry, given that all currently approved vaccines are administered via the intramuscular route. In this...

Subject

Nasal administration

Vaccination

Virology

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