Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck Cancer

Obradovic, Aleksandar; Graves, Diana; Korrer, Michael; Wang, Yu; Roy, Sohini; Naveed, Abdullah; Xu, Yaomin; Luginbuhl, Adam; Curry, Joseph; Gibson, Michael; Idrees, Kamran; Hurley, Paula; Jiang, Peng; Shirley Liu, X.; Uppaluri, Ravindra; G. Drake, Charles; Califano, Andrea; J. Kim, Young

doi:10.1158/1078-0432.ccr-21-3570

Public

Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck Cancer

Published in Clinical Cancer Research • Mar 9, 2022

Authors:

Aleksandar Obradovic

Diana Graves

Michael Korrer

Abstract

PURPOSE: Cancer-associated fibroblasts (CAF) have been implicated as potential mediators of checkpoint immunotherapy response. However, the extensive heterogeneity of these cells has precluded rigorous understanding of their immunoregulatory role in the tumor microenvironment. EXPERIMENTAL DESIGN: W...

Subject

Head and neck cancer

Immunotherapy

Medicine

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