Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

Cao, Yunlong; Wang, Jing; Jian, Fanchong; Xiao, Tianhe; Song, Weiliang; Yisimayi, Ayijiang; Huang, Weijin; Li, Qianqian; Wang, Peng; An, Ran; Wang, Jing; Wang, Yao; Niu, Xiao; Yang, Sijie; Liang, Hui; Sun, Haiyan; Li, Tao; Yu, Yuanling; Cui, Qianqian; Liu, Shuo; Yang, Xiaodong; Du, Shuo; Zhang, Zhiying; Hao, Xiaohua; Shao, Fei; Jin, Ronghua; Wang, Xiangxi; Xiao, Junyu; Wang, Youchun; Sunney Xie, Xiaoliang

doi:10.1038/s41586-021-04385-3

Public

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

Published in Nature • Dec 23, 2021

Authors:

Yunlong Cao

Jing Wang

Fanchong Jian

Abstract

Abstract The SARS-CoV-2 B.1.1.529 (Omicron) variant contains 15 mutations of the receptor-binding domain (RBD). How Omicron evades RBD-targeted neutralizing antibodies requires immediate investigation. Here we use high-throughput yeast display screening 1,2 to determine the profiles of RBD escaping ...

Subject

Neutralization

Antibody

Epitope

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