Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Lin, Simeng; A. Kennedy, Nicholas; Saifuddin, Aamir; Mūnoz Sandoval, Diana; J. Reynolds, Catherine; Castro Seoane, Rocio; Hermangild Kottoor, Sherine; P. Pieper, Franziska; Lin, Kai‐Min; K. Butler, David; Chanchlani, Neil; Nice, Rachel; Chee, Desmond; Bewshea, Claire; Janjua, Malik; J. McDonald, Timothy; Sebastian, Shaji; L. Alexander, James; Constable, Laura; Lee, James; Murray, Charles; Hart, Ailsa; M. Irving, Peter; Jones, Gareth‐Rhys; Kok, Klaartje; A Lamb, Christopher; W. Lees, Charlie; M. Altmann, Daniel; J. Boyton, Rosemary; Goodhand, James; Powell, Nick; Ahmad, Tariq; IBD study, CLARITY; Kok, Klaartje; Bokth, Farjhana; Cipriano, Bessie; Francia, C.; Khalid, Nosheen; Khatun, Hafiza; Kingston, Ashley; Lee, Irish; Lehmann, Anouk; Naik, Kinnari; Pabriaga, Elise; Plaatjies, Nicolene; Samuels, Kevin; Saich, Rebecca; Cousins, Hayley; Fraser, Wendy; Thomas, Rachel; A. Brown, Matthew; White, Benjamin; Kirkineziadis, Nikolaos; Tilley, Bernadette; Muhammed, Rafeeq; Bi, Rehana; Cotter, Catherine; Grove, Jayne; Hong, Kate; Howman, Ruth; J. Mitchell, Monica; Clayton, Sophie; Sultan, Sugrah; Rooney, Melanie; Cottrill, Charlotte; Singh, Salil; Dawe, Chris; Hull, R.; Silva, Nataliê; Manning, Jonathan; Finlayson, Lauren; Roebuck, Allison; Dawson, Joy; Sonwalkar, Sunil; Chambers, Naomi; Robinson, Matthew; Haigh, Andrew; Matapure, Lear; Raine, Tim; George, Varun; Kapizioni, Christina; Strongili, Konstantina; L. Thompson, Tina; Ahmed, Mohamed; K. Kontos, Christos; Bourges, Christophe; Barbutti, Isabella; E. Gozzard, Megan; Hendy, Philip; Bull, Rhian; Costa, Patricia; Davey, Lisa; Hannington, Hayley; Nundlall, Kribashnie; Martins, Catarina; Avanzi, Laura; Carungcong, Jaime; Barr, Sabrina; Appleby, Richard; C. Johnson, Emma; Phillis, Kath; Gascoyne, Rachel; Crowder, Amanda; Whileman, Amanda; London, Ian; Grounds, Jenny; Martin, Emmeline; Pajak, Susie; Price, Jude; Cawley, Kathryn; Dhar, Anjan; Brown, Ellen; Cowton, Amanda; Stamp, Kimberley; Warner, Ben; Stuart, Carmel; Lacey, Louise; de Silva, Shanika; Allcock, Clare; Harvey, Philip; Jones, Lesley; Cooke, Elise; Brooks, Johanne; Baker, Pearl; Beadle, Hannah; Cruz, Carina; Potter, Debbie; Collum, Joe; Masters, Farzana; Kumar, Aashish; Coetzee, Samantha; Peiu, Mihaela; Icke, Becky; Raj, Meena; Gaynor, Edward; Chadokufa, S.; Huggett, B.; Meghari, Hamza; El-Khouly, Sara; Kiparissi, Fevronia; Girshab, Waffa; Claridge, Andrew; Fowler, Emily; McCafferty, Laura; Christodoulides, Karolina; Clifford, Angela; Dawson, Patrick; Honap, Sailish; Lim, Samuel; P. Luber, Raphael; Mahiouz, Karina; Meade, Susanna; Raymode, Parizade; Reynolds, Rebecca; Stanton, Anna; Tripoli, Sherill; Hare, Naomi; Balachandran, Senthuran; North, Emma; North, Jessica; Browne, Bria; Jameson, Ella; Siaw, Y; Manzano, Lane; Segal, Jonathan; Al Bakir, Ibrahim; Khakoo, Imran; Thoua, Nora; Davidson, Katherine; Miah, Jagrul; Canclini, Lisa; Hall, Alex; Hayes, Melony; Myers, Sally; Talbot, Alison; Turnbull, Jack; Whitehead, Emma; Stamp, Katie; Pattinson, Alison; Mathew, Verghese; Sherris, Leanne; Harvey, A; Hicks, Lucy; Byrne, Tara-Marie; Cabreros, Leilani; Downing-Wood, Hannah; Hunter, Sophie; Prabhudev, Hemanth; Balarajah, Sharmili; Ibraheim, Hajir; Torkizadeh, Melissa; W. Lo, Jonathan; Liu, Zhigang; Sutherland, Helen; Wilhelmsen, Elva; Mackintosh, Katherine; Verma, Ajay; L. Sebastian, J.; Farhad Peerally, Mohammad; Raymode, Parizade; Guerdette, Anne-Marie; Kent, Alexandra; Meng Choong, Lee; Pantaloni, Benedetta; Ravdas, Pantelis; Vadamalayan, Babu; Foley, Stephen; Arnold, Becky; Heeley, Cheryl; Lovegrove, Wayne; Sowton, Donna; Allsop, Lynne; Gregory, Heidi; J Smith, Philip; Bretland, Giovanna; King, Sarah; Lofthouse, Martina; Rigby, Lindsey; Subramanian, Sreedhar; Tyrer, David; Martin, Kate; Probert, C; Kamperidis, Nikolaos; Adedoyin, Temi; Baden, Manisha; Brown, Jeannette; Chacko, F.; Cicchetti, Michela; Saifuddin, Mohammad; Yesupatham, Priya; Gowda, Rohit; Williams, Maureen; Kemp, Karen; Akhand, Rima; Gray, Glaxy; John, Anu; John, Maya; Mohammed, Tasnim; Sathe, Diamond; Jones, Natasha; Soren, Jennifer; Sprakes, Michael; Burton, Julie; Kane, Patricia; Lupton, Stephanie; Bartholomew, Jacqueline; MacFaul, George; Scaletta, Diane; Siamia, Loria; Williams, Felicity; Green, Chloe; Ver, Zeljka; A. Lamb, Christopher; Doona, Mary; Hogg, Ashleigh; Jeffrey, Lesley; King, Andrew; Speight, Ally; A Doyle, Jennifer; Owen, Ruth; Mowat, Craig; Rice, Debbie; MacFarlane, Susan; Macleod, Anne; Mohammed, Samera; Murray, Shona; Elliott, Anne; Anne Morris, Mary; Coke, Louise; Hindle, Grace; Kolokouri, Eirini; Wright, Catherine; Lee, Claire; Ward, Nicola; Dann, Adele; Lockett, Melanie; Cranfield, Charlotte; Jennings, Louise; Srivastava, Ankur; Ward, Lana; Jeynes, Nouf; Ranga, Poonam; Rajasekhar, Praveen; G. Gallagher, Lisa; Patterson, Linda; Ward, Jill; Basnett, Rae; Murphy, Judy; Parking, Lauren; Lawson, Emma; Short, Stacey; Devadason, David; W. Moran, Gordon; Khan, Neelam; Tarr, Lauren; Olivia, Charmaine; K. Limdi, Jimmy; Goulden, Kay; Javed, Asad; Brooks McKenzie, L.; Bhandari, Pradeep; Baker-Moffatt, Michelle; Dash, Joanne; Le Poidevin, Alison; Downe, Hayley; Bombeo, Lucille; Blackman, Helen; A. Wiles, Alan; Bloxham, Hannah; Dias, José; Nadar, Evelyn; Curgenven, Hollie; Macdonald, Jonathan; Finan, Shona; McMeeken, Faye; Mahmood, Misbah; Shields, Stephanie; Paul Seenan, John; DeSilva, Des; Malkakorpi, Susanna; Carson, Rachel; Whiteoak, Simon; Edger-Earley, Kelli; Vamplew, Luke; Ingram, Sarah; Botfield, Sharon; Hammonds, Fiona; James, Clare; Ahmad, Tariq; O. Aspinall, G.; Hawkins, Sarah; Marriott, Suzie; Redstone, Clare; Windak, Halina; Adam, Ana-Marie; Mabb, Hannah; Murray, Charles; Diaba, Cynthia; Joseph, Fexy; Pakou, Glykeria; Gleeson, Yvonne; Berrill, James; Stroud, Natalie; Pothecary, Carla; Roche, L; Turner, Keri; Deering, Lisa; Israel, Lynda; Baker, Evelyn; Cutler, Sean; Evans, R.; Nash, Maxine; Mallison, Georgina; Roynon, Anna; Gordon, John; Levell, Emma; Zagalo, Silvia; Fraser, Wendy; Hoad, Ina; Kirkineziadis, Nikolaos; K. Russell, Richard; Henderson, Paul; Millar, Margaret; Fagbemi, Andrew; Jennings, Felicia; Mayor, Imelda; Wilson, Jill; Alexakis, Christopher; Michalak, Natalia; B. Saunders, John; Burton, Helen; Cambridge, Vanessa; Clark, Tonia; Ekblad, Charlotte; Hierons, Sarah; Katebe, Joyce; Saunsbury, Emma; Perry, Rachel; Brookes, Matthew; Davies, Kathryn; Green, Marie; Plumbe, Ann; Ormerod, Clare; Christensen, Helen; Keen, Anne; Ogor, Jonathan; Anthony, Alpha; Newitt, Emily; Trim, Fiona; Casey, Ruth; Seymour, Katherine; Fogden, Edward; Russell, K; Phillips, Anne; Abdulla, Muaad; Butterworth, Jeff; Adams, Colene; Buckingham, Elizabeth; Childs, Danielle; Magness, Alison; Stickley, Jo; Motherwell, Nichola; Tonks, Louise; Gibson, Hannah; Pajak, Stanislawa; Thomas, Caradog; Brinkworth, Elaine; Connor, Lynda; Cook, Amanda; Rees, Tabitha; Harford, Rachel; Wesley, Emma; Moss, Alison; Lucas, Jacob; Lorimer, Claire; Oleary, Maria; Dixon, Maxine; Ramadas, Arvind; Tregonning, Julie; Okeke, O.; Jackson, Wendy; Koumoutsos, Ioannis; George, Viji; Kunhunny, Swapna; Laverick, Sophie; Anderson, Isla; Smith, Sophie; Patel, Kamal; Ali, Mariam; Mhandu, Hilda; Rana, Aleem; Spears, Katherine; Teixeira, Joana; Pollok, Richard; Mencias, Mark; Seaward, Abigail; Sousa, Jessica; Said, Nooria; Soomaroo, Mark; Raspa, Valentina; Tacouri, Asha; Reps, Nicholas; Martin, Rebecca; P. Selinger, Christian; Carbonell, J; Onovira, Felicia; Quartey, Doris; L’Anson, Alice; Ashworth, Andrew; J. Bailey, Jessica; Dunn, Angie; Mahmood, Zahid; Campbell, Racheal; Marsh, Liane; Rahman, Monira; J. Davies, Sarah; Habibi, Ruth; Jessup-Dunton, Ellen; Joefield, Teishel; Layug, Reina; Patel, Vinod; Vere, Joanne; Turner, Victoria; Kilroy, Susan; Walker, Gareth; Atkins, Stacey; Growdon, Jasmine; McNeill, Charlotte; Cooney, Rachel; Bennett, Lillie; Bowlas, Louise; Shariff, Sharafaath; Fraser, Aileen; Punnette, Dwayne; Bishop-Hurman, Charlotte; Undrell, Elizabeth; Belfield, Katherine; Din, Said; Addleton, Catherine; C. Appleby, M.; Brown, Johanna; Holding, Kathleen; Hooper, Patricia; de Caestecker, John; Watchorn, Olivia; Hayward, Chris; Inniss, Susan; Pritchard, Lucy; Rudge, Karen; Carney, Amanda; Andreyev, Jervoise; Hayhurst, Caroline; Lockwood, Carol; Osborne, Lynn; Roper, Amanda; Warner, Karen; Hindle, Julia; Watt, Caroline; Szymiczek, Kinga; Mehta, Shameer; Bell, James; Blad, William; Whitley, Lisa; Dhamaraj, Durai; R. Baker, Mark; John Sivamurugan, Elizabeth; Evans, Mim; Cummings, Fraser; Harris, Clare; Jones, Amy; Krauze, Liga; Rahmany, Sohail; Earl, M; Vowles, Jenny; Torokwa, Audrey; Petrova, Mirela; Procter, Andrew; Stanley, Jo; Silvamoniz, Claudia; Bettey, Marion; Wahid, Amar; Morrison, Zoë; Thomas-Turner, Rhian; Yendle, Louise; B. A. Muller, J.; Mitchell, Marcus; M. Kirkwood, John; Barnes, Anna; Chaudhary, Rakesh; Claridge, M.; Ellis, Chiara; Kemp, Cheryl; Tobi, Ogwa; Milton, Jentus; Johnston, Emma; Oblak, Metod; Godden, Jo; W. Lees, Charlie; Alexander, Debbie; Covil, Kate; Derikx, Lauranne; Siakavellas, Sryros; C. Baxter, Helen; Robertson, Scott; C. Smith, Linda; Poulose, Beena; Colemam, Anne; Balint, Margareta; Rhys-Jones, Gareth; Johns, Kerrie; Hughes, Rachel; Phipps, Janet; Taylor, Abigail; Macphee, Catherine; Brooks, Suzanne; Smith, Katie; Howard, Linda; Wood, Dianne; Muddu, Ajay; Barman, L; Mallinson, Janine; Neale, Tania; Ionita, D; Elliot, Kerry; Turnball, Alison; Thomas, Iola; S. Andrews, Kelly; Sutton, Jonathon; Mulvaney Jones, Caroline; Roberts, Julia; Bishop, Jeannie

doi:10.1038/s41467-022-28517-z

Public

Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Published in Nature Communications • Mar 16, 2022

Authors:

Simeng Lin

Nicholas A. Kennedy

Aamir Saifuddin

Abstract

Anti tumour necrosis factor (anti-TNF) drugs increase the risk of serious respiratory infection and impair protective immunity following pneumococcal and influenza vaccination. Here we report SARS-CoV-2 vaccine-induced immune responses and breakthrough infections in patients with inflammatory bowel ...

Subject

Vedolizumab

Infliximab

Medicine

Research Assistant

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