Fusobacterium nucleatum reduces METTL3-mediated m6A modification and contributes to colorectal cancer metastasis

Chen, Shujie; Zhang, Lu; Li, Mengjie; Zhang, Ying; Sun, Meng; Wang, Lingfang; Wang, Lingfang; Lin, Jiebo; Cui, Yun; Chen, Qian; Jin, Chenqi; Li, Xiang; Wang, Boya; Chen, Hao; Zhou, Tianhua; Wang, Liangjing; Wang, Liangjing; Hsu, Chih-Hung; Zhuo, Wei

doi:10.1038/s41467-022-28913-5

Public

Fusobacterium nucleatum reduces METTL3-mediated m6A modification and contributes to colorectal cancer metastasis

Published in Nature Communications • Mar 10, 2022

Authors:

Shujie Chen

Lu Zhang

Mengjie Li

Abstract

Abstract Microbiota-host interactions play critical roles in colorectal cancer (CRC) progression, however, the underlying mechanisms remain elusive. Here, we uncover that Fusobacterium nucleatum ( F. nucleatum ) induces a dramatic decline of m 6 A modifications in CRC cells and patient-derived xenog...

Subject

Fusobacterium nucleatum

Downregulation and upregulation

Colorectal cancer

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