TET2 regulates osteoclastogenesis by modulating autophagy in OVX-induced bone loss

Chen, Yang; Tao, Huaqiang; Zhang, Haifeng; Xia, Yu; Bai, Jiaxiang; Ge, Gaoran; Li, Wenming; Zhang, Wei; Xiao, Long; Xu, Yaozeng; Wang, Zhirong; Gu, Ye; Yang, Huilin; Liu, Yu; Geng, Dechun

doi:10.1080/15548627.2022.2048432

Public

TET2 regulates osteoclastogenesis by modulating autophagy in OVX-induced bone loss

Published in Autophagy • Mar 8, 2022

Authors:

Yang Chen

Huaqiang Tao

Haifeng Zhang

Abstract

Increased bone resorption by osteoclasts after estrogen deficiency is the main cause of postmenopausal osteoporosis. TET2 (tet methylcytosine dioxygenase 2) is a DNA demethylase that regulates cellular function and differentiation potential. Macroautophagy/autophagy maintains cellular homeostasis by...

Subject

BECN1

Autophagy

Osteoclast

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