Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: prospective observational study

S. Lauring, Adam; W. Tenforde, Mark; D. Chappell, James; Gaglani, Manjusha; A. Ginde, Adit; McNeal, Tresa; Ghamande, Shekhar; J. Douin, David; Keipp Talbot, H.; D. Casey, Jonathan; M. Mohr, Nicholas; Zepeski, Anne; I. Shapiro, Nathan; W. Gibbs, Kevin; Clark Files, D.; N. Hager, David; Shehu, Arber; E. Prekker, Matthew; L. Erickson, Heidi; C. Exline, Matthew; N. Gong, Michelle; Mohamed, Amira; J. Johnson, Nicholas; Srinivasan, Vasisht; S. Steingrub, Jay; D. Peltan, Ithan; M. Brown, Samuel; T. Martin, Emily; S. Monto, Arnold; Khan, Akram; L. Hough, Catherine; W. Busse, Laurence; C. ten Lohuis, Caitlin; Duggal, Abhijit; G. Wilson, Jennifer; June Gordon, Alexandra; Qadir, Nida; Y. Chang, Steven; Mallow, Christopher; Rivas, Carolina; M. Babcock, Hilary; H. Kwon, Jennie; Halasa, Natasha; G. Grijalva, Carlos; W. Rice, Todd; B. Stubblefield, William; Baughman, Adrienne; N. Womack, Kelsey; P. Rhoads, Jillian; J. Lindsell, Christopher; W. Hart, Kimberly; Zhu, Yuwei; Adams, Katherine; J. Schrag, Stephanie; M. Olson, Samantha; Kobayashi, Miwako; R. Verani, Jennifer; M. Patel, Manish; H. Self, Wesley

doi:10.1136/bmj-2021-069761

Public

Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: prospective observational study

Published in BMJ • Mar 9, 2022

Authors:

Adam S. Lauring

Mark W. Tenforde

James D. Chappell

Abstract

OBJECTIVES: To characterize the clinical severity of covid-19 associated with the alpha, delta, and omicron SARS-CoV-2 variants among adults admitted to hospital and to compare the effectiveness of mRNA vaccines to prevent hospital admissions related to each variant. DESIGN: Case-control study. SETT...

Subject

Medicine

Coronavirus disease 2019 (COVID-19)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

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