Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia

Khabirova, Eleonora; Jardine, Laura; H. H. Coorens, Tim; Webb, Simone; D. Treger, Taryn; Engelbert, Justin; Porter, Tarryn; Prigmore, Elena; Collord, Grace; Piapi, Alice; A. Teichmann, Sarah; Inglott, Sarah; Williams, Owen; Heidenreich, Olaf; D. Young, Matthew; Straathof, Karin; Bomken, Simon; Bartram, Jack; Haniffa, Muzlifah; Behjati, Sam

doi:10.1038/s41591-022-01720-7

Public

Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia

Shared by NobleBlocks on Mar 14, 2022 • 12:00 AM UTC

Authors:

Eleonora Khabirova

Laura Jardine

Tim H. H. Coorens

Abstract

Abstract KMT2A- rearranged infant ALL is an aggressive childhood leukemia with poor prognosis. Here, we investigated the developmental state of KMT2A -rearranged infant B-cell acute lymphoblastic leukemia (B-ALL) using bulk messenger RNA (mRNA) meta-analysis and examination of single lymphoblast tra...

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