The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD

Günes Günsel, Gizem; M. Conlon, Thomas; Jeridi, Aicha; Kim, Rinho; Ertüz, Zeynep; J. Lang, Niklas; Ansari, Meshal; Novikova, Mariia; Jiang, Dongsheng; Strunz, Maximilian; Gaianova, Mariia; Hollauer, Christine; Gabriel, Christina; Angelidis, Ilias; Doll, Sebastian; C. Pestoni, Jeanine; L. Edelmann, Stephanie; Sophia Kohlhepp, Marlene; Guillot, Adrien; Bassler, Kevin; P. Van Eeckhoutte, Hannelore; Kayalar, Özgecan; Konyalilar, Nur; Kanashova, Tamara; Rodius, Sophie; Ballester-López, Carolina; M. Genes Robles, Carlos; Smirnova, Natalia; Rehberg, Markus; Agarwal, Charu; Krikki, Ioanna; Piavaux, Benoit; E. Verleden, Stijn; Vanaudenaerde, Bart; Königshoff, Melanie; Dittmar, Gunnar; R. Bracke, Ken; L. Schultze, Joachim; Watz, Henrik; Eickelberg, Oliver; Stoeger, Tobias; Burgstaller, Gerald; Tacke, Frank; Heissmeyer, Vigo; Rinkevich, Yuval; Bayram, Hasan; B. Schiller, Herbert; Conrad, Marcus; Schneider, Robert; Önder Yildirim, Ali

doi:10.1038/s41467-022-28809-4

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The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD

Shared by NobleBlocks on Mar 14, 2022 • 12:00 AM UTC

Authors:

Gizem Günes Günsel

Thomas M. Conlon

Aicha Jeridi

Abstract

Abstract Extravasation of monocytes into tissue and to the site of injury is a fundamental immunological process, which requires rapid responses via post translational modifications (PTM) of proteins. Protein arginine methyltransferase 7 (PRMT7) is an epigenetic factor that has the capacity to mono-...

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