Tumor Derived Extracellular Vesicles Drive T Cell Exhaustion in Tumor Microenvironment through Sphingosine Mediated Signaling and Impacting Immunotherapy Outcomes in Ovarian Cancer

Gupta, Prachi; P. Kadamberi, Ishaque; Mittal, Sonam; Tsaih, Shirng‐Wern; George, Jasmine; Kumar, Sudhir; K. Vijayan, Dileep; Geethadevi, Anjali; Parashar, Deepak; Topchyan, Paytsar; A. McAlarnen, Lindsey; F. Volkman, Brian; Cui, Weiguo; Y. J. Zhang, Kam; Di Vizio, Dolores; Chaluvally–Raghavan, Pradeep; Pradeep, Sunila

doi:10.1002/advs.202104452

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Tumor Derived Extracellular Vesicles Drive T Cell Exhaustion in Tumor Microenvironment through Sphingosine Mediated Signaling and Impacting Immunotherapy Outcomes in Ovarian Cancer

Published in Advanced Science • Mar 15, 2022

Authors:

Prachi Gupta

Ishaque P. Kadamberi

Sonam Mittal

Abstract

SPHK1 (sphingosine kinase-1) catalyzes the phosphorylation of sphingosine to sphingosine-1-phosphate (S1P), is found to be highly expressed in solid tumors. Here, extracellular vesicles (EVs) are identified as the key transporters of SPHK1 to the tumor microenvironment. Consequently, SPHK1-packaged ...

Subject

Tumor microenvironment

Sphingosine

Sphingosine kinase 1

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