Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes

Mei, Xiu; Geng, Kang; Yuen Kwan Law, Betty; Wang, Peng; Li Pu, Yue; Chen, Qing; Xu, Hui; Tan, Xiao; Zhe Jiang, Zong; Xu, Yong

doi:10.1007/s10565-021-09692-z

Public

Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes

Published in Cell Biology and Toxicology • Mar 2, 2022

Authors:

Xiu Mei

Kang Geng

Betty Yuen Kwan Law

Abstract

Diabetic cardiomyopathy (DCM) is characterized by lipid accumulation, mitochondrial dysfunction, and aseptic inflammatory activation. Mitochondria-derived cytosolic DNA has been reported to induce inflammation by activating cyclic GMP-AMP synthase (cGAS)/the stimulator of interferon genes (STING) pa...

Subject

Stimulator of interferon genes

IRF3

Sting

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