Rare coding variants in ten genes confer substantial risk for schizophrenia

Singh, Tarjinder; Poterba, Timothy; Curtis, David; Akil, Huda; Al Eissa, Mariam; D. Barchas, Jack; Bass, Nicholas; B. Bigdeli, Tim; Breen, Gerome; J. Bromet, Evelyn; Buckley, P.F.; E. Bunney, William; Bybjerg‐Grauholm, Jonas; Byerley, William; B. Chapman, Sinéad; J. Chen, Wei; Churchhouse, Claire; Craddock, Nicholas; Cusick, Caroline; E. DeLisi, Lynn; Dodge, Sheila; Escamilla, Michael; Eskelinen, Saana; H. Fanous, Ayman; V. Faraone, Stephen; Fiorentino, Alessia; C. Francioli, Laurent; Gabriel, Stacey; Gage, Diane; A. Gagliano Taliun, Sarah; Ganna, Andrea; Genovese, Giulio; C. Glahn, David; Grove, Jakob; Hall, Mei‐Hua; Hämäläinen, Eija; Heyne, Henrike; Holi, Matti; M. Hougaard, David; P. Howrigan, Daniel; Huang, Hailiang; Hwu, Hai‐Gwo; S. Kahn, René; Min Kang, Hyun; J. Karczewski, Konrad; Kirov, George; A. Knowles, James; S. Lee, Francis; S. Lehrer, Douglas; Lescai, Francesco; Malaspina, Dolores; R. Marder, Stephen; A. McCarroll, Steven; M. McIntosh, Andrew; Medeiros, Helena; Milani, Lili; P. Morley, Christopher; W. Morris, Derek; Bo Mortensen, Preben; Myers, R; Nordentoft, Merete; L. O’Brien, Niamh; Maria Olivares, Ana; Öngür, Döst; H. Ouwehand, Willem; S. Palmer, Duncan; Paunio, Tiina; Quested, Digby; Hyman Rapaport, Mark; Rees, Elliott; Rollins, Brandi; Kyle Satterstrom, F.; F. Schatzberg, Alan; M. Scolnick, Edward; J. Scott, Laura; I. Sharp, Sally; Sklar, Pamela; W. Smoller, Jordan; L. Sobell, Janet; Solomonson, Matthew; A. Stahl, Eli; Stevens, Christine; Suvisaari, Jaana; Tiao, Grace; J. Watson, Stanley; A. Watts, Nicholas; Blackwood, Douglas; D. Børglum, Anders; M. Cohen, Bruce; Corvin, Aiden; Esko, Tõnu; B. Freimer, Nelson; J. Glatt, Stephen; M. Hultman, Christina; McQuillin, Andrew; Palotie, Aarno; N. Pato, Carlos; T. Pato, Michele; E. Pulver, Ann; St Clair, David; T. Tsuang, Ming; P. Vawter, Marquis; Walters, James; Werge, Thomas; A. Ophoff, Roel; F. Sullivan, Patrick; J. Owen, Michael; Boehnke, Michael; O‘Donovan, Michael; M. Neale, Benjamin; J. Daly, Mark

doi:10.1038/s41586-022-04556-w

Public

Rare coding variants in ten genes confer substantial risk for schizophrenia

Published in Nature • Apr 8, 2022

Authors:

Tarjinder Singh

Timothy Poterba

David Curtis

Abstract

Rare coding variation has historically provided the most direct connections between gene function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 schizophrenia cases and 97,322 controls, we implicate ultra-rare coding variants (URVs) in 10 genes as conferring substantial risk ...

Subject

Gene

Genetics

Schizophrenia (object-oriented programming)

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