SARS-CoV-2 BA.1 variant is neutralized by vaccine booster–elicited serum but evades most convalescent serum and therapeutic antibodies

Lusvarghi, Sabrina; Pollett, Simon; Nath Neerukonda, Sabari; Wang, Wei; Wang, Richard; Vassell, Russell; J Epsi, Nusrat; C Fries, Anthony; K. Agan, Brian; A Lindholm, David; Colombo, Christopher; Mody, Rupal; Ewers, Evan; Lalani, Tahaniyat; Ganesan, Anuradha; Goguet, Emilie; Hollis-Perry, Monique; A. Coggins, Si’Ana; P. Simons, Mark; C. Katzelnick, Leah; Wang, Gregory; R. Tribble, David; Bentley, Lisa; E. Eakin, Ann; C. Broder, Christopher; J. Erlandson, Karl; D. Laing, Eric; Burgess, Timothy; Mitre, Edward; D. Weiss, Carol

doi:10.1126/scitranslmed.abn8543

Public

SARS-CoV-2 BA.1 variant is neutralized by vaccine booster–elicited serum but evades most convalescent serum and therapeutic antibodies

Published in Science Translational Medicine • Apr 5, 2022

Authors:

Sabrina Lusvarghi

Simon Pollett

Sabari Nath Neerukonda

Abstract

The rapid spread of the highly contagious Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) along with its high number of mutations in the spike gene has raised alarms about the effectiveness of current medical countermeasures. To address this concern, we measured the n...

Subject

Antibody

Neutralization

Titer

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