Single-cell RNA-seq reveals cell type–specific molecular and genetic associations to lupus

K. Perez, Richard; Grace Gordon, M.; Subramaniam, Meena; Cheol Kim, Min; C. Hartoularos, George; Targ, Sasha; Sun, Yang; Ogorodnikov, Anton; Bueno, Raymund; Lu, Andrew; Thompson, Michael; Rappoport, Nadav; Dahl, Andrew; Lanata, Cristina; Matloubian, Mehrdad; Maliskova, Lenka; S. Kwek, Serena; Li, Tony; Slyper, Michal; Waldman, Julia; Dionne, Danielle; Rozenblatt–Rosen, Orit; Fong, Lawrence; Dall’Era, Maria; Balliu, Brunilda; Regev, Aviv; Yazdany, Jinoos; A. Criswell, Lindsey; Zaitlen, Noah; Ye, Chun

doi:10.1126/science.abf1970

Public

Single-cell RNA-seq reveals cell type–specific molecular and genetic associations to lupus

Published in Science • Apr 7, 2022

Authors:

Richard K. Perez

M. Grace Gordon

Meena Subramaniam

Abstract

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. Knowledge of circulating immune cell types and states associated with SLE remains incomplete. We profiled more than 1.2 million peripheral blood mononuclear cells (162 cases, 99 controls) with multiplexed single-cell RNA seque...

Subject

Biology

Cell type

Peripheral blood mononuclear cell

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