Omicron breakthrough infection drives cross-variant neutralization and memory B cell formation

Quandt, Jasmin; Muik, Alexander; Salisch, Nadine; Gaby Lui, Bonny; Lutz, Sebastian; Krüger, Kimberly; Wallisch, Ann-Kathrin; Adams‐Quack, Petra; Bacher, Maren; Finlayson, Andrew; Ozhelvaci, Orkun; Vogler, Isabel; Grikscheit, Katharina; Hoehl, Sebastian; Goetsch, Udo; Ciesek, Sandra; Türeci, Özlem; Şahin, Uğur

doi:10.1101/2022.04.01.486695

Public

Omicron breakthrough infection drives cross-variant neutralization and memory B cell formation

Published in bioRxiv (Cold Spring Harbor Laboratory) • Apr 1, 2022

Authors:

Jasmin Quandt

Alexander Muik

Nadine Salisch

Abstract

Abstract Omicron is the evolutionarily most distinct SARS-CoV-2 variant (VOC) to date and displays multiple amino acid alterations located in neutralizing antibody sites of the spike (S) protein. We report here that Omicron breakthrough infection in BNT162b2 vaccinated individuals results in strong ...

Subject

Neutralization

Antibody

Virology

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