Cardiac Resident Macrophage-Derived Legumain Improves Cardiac Repair by Promoting Clearance and Degradation of Apoptotic Cardiomyocytes After Myocardial Infarction

Jia, Daile; Chen, Siqin; Bai, Peiyuan; Luo, Chentao; Liu, Jin; Sun, Aijun; Ge, Junbo

doi:10.1161/circulationaha.121.057549

Public

Cardiac Resident Macrophage-Derived Legumain Improves Cardiac Repair by Promoting Clearance and Degradation of Apoptotic Cardiomyocytes After Myocardial Infarction

Published in Circulation • Apr 18, 2022

Authors:

Daile Jia

Siqin Chen

Peiyuan Bai

Abstract

Background: Cardiac resident macrophages are self-maintaining and originate from embryonic hematopoiesis. After myocardial infarction, cardiac resident macrophages are responsible for the efficient clearance and degradation of apoptotic cardiomyocytes (efferocytosis). This process is required for in...

Subject

Medicine

Myocardial infarction

Apoptosis

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