Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer

Ouyang, Shumin; Li, Huaxuan; Lou, Linlin; Huang, Qiuyao; Zhang, Zhenhua; Mo, Jianshan; Li, Min; Lu, Jiaye; Zhu, Kai; Chu, Yunjie; Ding, Wen; Zhu, Jianzheng; Lin, Ziyou; Zhong, Lin; Wang, Junjian; Yue, Peibin; Turkson, James; Liu, Peiqing; Wang, Yuanxiang; Zhang, Xiaolei

doi:10.1016/j.redox.2022.102317

Public

Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer

Published in Redox Biology • Apr 21, 2022

Authors:

Shumin Ouyang

Huaxuan Li

Linlin Lou

Abstract

Chemotherapy is still one of the principal treatments for gastric cancer, but the clinical application of 5-FU is limited by drug resistance. Here, we demonstrate that ferroptosis triggered by STAT3 inhibition may provide a novel opportunity to explore a new effective therapeutic strategy for gastri...

Subject

Cancer research

Cancer

GPX4

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