Declining Levels and Bioavailability of IGF-I in Cardiovascular Aging Associate With QT Prolongation–Results From the 1946 British Birth Cohort

Charalambous, Christos; Moon, James; M.P. Holly, Jeff; Chaturvedi, Nish; D. Hughes, Alun; Captur, Gabriella

doi:10.3389/fcvm.2022.863988

Public

Declining Levels and Bioavailability of IGF-I in Cardiovascular Aging Associate With QT Prolongation–Results From the 1946 British Birth Cohort

Published in Frontiers in Cardiovascular Medicine • Apr 22, 2022

Authors:

Christos Charalambous

James Moon

Jeff M.P. Holly

Abstract

Background As people age, circulating levels of insulin-like growth factors (IGFs) and IGF binding protein 3 (IGFBP-3) decline. In rat cardiomyocytes, IGF-I has been shown to regulate sarcolemmal potassium channel activity and late sodium current thus impacting cardiac repolarization and the heart r...

Subject

Medicine

Interquartile range

QT interval

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