The biogenesis and secretion of exosomes and multivesicular bodies (MVBs): Intercellular shuttles and implications in human diseases

Xu, Minxue; Ji, Jie; Jin, Dandan; Wu, Yue; Wu, Tong; Lin, Renjie; Zhu, Shengze; Jiang, Feng; Ji, Yifei; Bao, Baijun; Li, Mei; Xu, Weisong; Xiao, Mingbing

doi:10.1016/j.gendis.2022.03.021

Public

The biogenesis and secretion of exosomes and multivesicular bodies (MVBs): Intercellular shuttles and implications in human diseases

Published in Genes & Diseases • Apr 22, 2022

Authors:

Minxue Xu

Jie Ji

Dandan Jin

Abstract

Exosomes carry and transmit signaling molecules used for intercellular communication. The generation and secretion of exosomes is a multistep interlocking process that allows simultaneous control of multiple regulatory sites. Protein molecules, mainly RAB GTPases, cytoskeletal proteins and soluble N...

Subject

Microvesicles

Cell biology

Secretion

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