miR-124-3p delivered by exosomes from heme oxygenase-1 modified bone marrow mesenchymal stem cells inhibits ferroptosis to attenuate ischemia–reperfusion injury in steatotic grafts

Wu, Longlong; Tian, Xuan; Zuo, Huaiwen; Zheng, Weiping; Li, Xiang; Yuan, Mengshu; Tian, Xiaorong; Song, Hongli

doi:10.1186/s12951-022-01407-8

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miR-124-3p delivered by exosomes from heme oxygenase-1 modified bone marrow mesenchymal stem cells inhibits ferroptosis to attenuate ischemia–reperfusion injury in steatotic grafts

Shared by NobleBlocks on Apr 22, 2022 • 12:00 AM UTC

Authors:

Longlong Wu

Xuan Tian

Huaiwen Zuo

Abstract

Abstract Background Steatotic livers tolerate ischemia–reperfusion injury (IRI) poorly, increasing the risk of organ dysfunction. Ferroptosis is considered the initiating factor of organ IRI. Heme oxygenase oxygen-1 (HO-1)-modified bone marrow mesenchymal stem cells (BMMSCs) (HO-1/BMMSCs) can reduce...

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