Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice

Simon, Matthew; Xun Wang, Marie; Ismail, Ozama; Braun, Molly; G. Schindler, Abigail; Reemmer, Jesica; Wang, Zhongya; A. Haveliwala, Mariya; P. O’Boyle, Ryan; Han, Warren; Roese, Natalie; R. Grafe, Marjorie; L. Woltjer, Randall; Boison, Detlev; J. Iliff, Jeffrey

doi:10.1186/s13195-022-00999-5

Public

Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice

Published in Alzheimer s Research & Therapy • Apr 26, 2022

Authors:

Matthew Simon

Marie Xun Wang

Ozama Ismail

Abstract

BACKGROUND: Slowed clearance of amyloid β (Aβ) is believed to underlie the development of Aβ plaques that characterize Alzheimer's disease (AD). Aβ is cleared in part by the glymphatic system, a brain-wide network of perivascular pathways that supports the exchange of cerebrospinal and brain interst...

Subject

Glymphatic system

Aquaporin 4

Interstitial fluid

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