Alteplase Compared to Tenecteplase in patients with Acute Ischemic Stroke (AcT) Trial: Protocol for a Pragmatic Registry linked Randomized Clinical Trial

T. Sajobi, Tolulope; Singh, Nishita; Almekhlafi, Mohammed; Buck, Brian; Ademola, Ayoola; B. Coutts, Shelagh; Deschaintre, Yan; Khosravani, Houman; Appireddy, Ramana; Moreau, F.; Phillips, Stephen; Gubitz, Gord; Tkach, Aleksander; Catanese, Luciana; Dowlatshahi, Dar; Medvedev, George; Mandzia, Jennifer; Pikula, Aleksandra; Shankar, Jai; Williams, Heather; S. Field, Thalia; Manosalva, Alejandro; Siddiqui, Muzaffar; Zafar, Atif; Imoukhoude, Oje; Hunter, Gary; Sehgal, Arshia; Zhang, Qiao; Doram, Craig; D. Hill, Michael; Shamy, Michel; Kenney, Carol; H. Swartz, Richard; K. Menon, Bijoy

doi:10.1161/svin.121.000447

Public

Alteplase Compared to Tenecteplase in patients with Acute Ischemic Stroke (AcT) Trial: Protocol for a Pragmatic Registry linked Randomized Clinical Trial

Published in Stroke Vascular and Interventional Neurology • May 2, 2022

Authors:

Tolulope T. Sajobi

Nishita Singh

Mohammed Almekhlafi

Abstract

Background : Intravenous thrombolysis with alteplase is widely used in acute ischemic stroke patients presenting early after symptom onset. Recent phase II trials have suggested that intravenous tenecteplase may be safer and associated with higher early reperfusion rates as compared to alteplase. Th...

Subject

Medicine

Tenecteplase

Thrombolysis

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