SARS-CoV-2 induces barrier damage and inflammatory responses in the human iPSC-derived intestinal epithelium

Yamada, Shigeru; Noda, Takamasa; Okabe, Kaori; Yanagida, Shota; Nishida, Motohiro; Kanda, Yasunari

doi:10.1016/j.jphs.2022.04.010

Public

SARS-CoV-2 induces barrier damage and inflammatory responses in the human iPSC-derived intestinal epithelium

Published in Journal of Pharmacological Sciences • May 2, 2022

Authors:

Shigeru Yamada

Takamasa Noda

Kaori Okabe

Abstract

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread and led to global health crises. COVID-19 causes well-known respiratory failure and gastrointestinal symptoms, such as diarrhea, nausea, and vomiting. Thus, human gastroint...

Subject

Induced pluripotent stem cell

Tight junction

Proinflammatory cytokine

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