Targeted protein degradation: mechanisms, strategies and application.
Published in Signal transduction and targeted therapy • Apr 4, 2022
Authors:,,
Lin Zhao
Jia Zhao
Kunhong Zhong
Abstract
Traditional drug discovery mainly focuses on direct regulation of protein activity. The development and application of protein activity modulators, particularly inhibitors, has been the mainstream in drug development. In recent years, PROteolysis TArgeting Chimeras (PROTAC) technology has emerged as...
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