Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer's Disease

Budd Haeberlein, Samantha; Aisen, Paul; Barkhof, Frederik; Chalkias, Spyros; Chen, Tianle; Cohen, Sarah; Dent, Gersham; Hansson, Oskar; Harrison, Katie; von Hehn, Christian; Iwatsubo, Takeshi; Mallinckrodt, Craig; Mummery, Cath; Kandadi Muralidharan, Kumar; Nestorov, Ivan; Nisenbaum, Laura; Rajagovindan, Raj; Skordos, LeAnne; Tian, Y.; H. van Dyck, Christopher; Vellas, Bruno; Wu, Sifan; Zhu, Ying; Sandrock, Alfred

doi:10.14283/jpad.2022.30

Public

Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer's Disease

Published in The Journal of Prevention of Alzheimer s Disease • Mar 15, 2022

Authors:

Samantha Budd Haeberlein

Paul Aisen

Frederik Barkhof

Abstract

BACKGROUND: Alzheimer's disease is a progressive, irreversible, and fatal disease for which accumulation of amyloid beta is thought to play a key role in pathogenesis. Aducanumab is a human monoclonal antibody directed against aggregated soluble and insoluble forms of amyloid beta. OBJECTIVES: We ev...

Subject

Medicine

Placebo

Clinical endpoint

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