Hypermethylation of <i>RAD9A</i> intron 2 in childhood cancer patients, leukemia and tumor cell lines suggest a role for oncogenic transformation.

D, Galetzka; J, Böck; L, Wagner; M, Dittrich; O, Sinizyn; M, Ludwig; H, Rossmann; C, Spix; M, Radsak; P, Scholz-Kreisel; J, Mirsch; M, Linke; W, Brenner; M, Marron; A, Poplawski; T, Haaf; H, Schmidberger; D, Prawitt

doi:10.17179/excli2021-4482

Public

Hypermethylation of RAD9A intron 2 in childhood cancer patients, leukemia and tumor cell lines suggest a role for oncogenic transformation.

Shared by NobleBlocks on Jan 7, 2022 • 12:00 AM UTC

Authors:

Galetzka D

Böck J

Wagner L

Abstract

Most childhood cancers occur sporadically and cannot be explained by an inherited mutation or an unhealthy lifestyle. However, risk factors might trigger the oncogenic transformation of cells. Among other regulatory signals, hypermethylation of RAD9A intron 2 is responsible for the increased express...

Subject

Leukemia

DNA repair

hypermethylation

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