Complement activation induces excessive T cell cytotoxicity in severe COVID-19

Georg, Philipp; Astaburuaga-García, Rosario; Bonaguro, Lorenzo; Brumhard, Sophia; Michalick, Laura; J. Lippert, Lena; Kostevc, Tomislav; Gäbel, Christiane; Schneider, Maria; Streitz, Mathias; Demichev, Vadim; D. Gemünd, Ioanna; Barone, Matthias; Tober‐Lau, Pinkus; T. Helbig, Elisa; Hillus, David; A. Petrov, L.; Stein, Julia; Dey, Hannah-Philine; Paclik, Daniela; Iwert, Christina; Mülleder, Michael; Kaur Aulakh, Simran; Djudjaj, Sonja; D. Bülow, Roman; E. Mei, Henrik; Schulz, Axel; Thiel, Andreas; Hippenstiel, Stefan; Saliba, Antoine‐Emmanuel; Eils, Roland; Lehmann, Irina; Mall, Marcus; Stricker, Sebastian; Röhmel, Jobst; M. Corman, Victor; Beule, Dieter; Wyler, Emanuel; Landthaler, Markus; Obermayer, Benedikt; von Stillfried, Saskia; Boor, Peter; Demir, Münevver; Wesselmann, Hans; Suttorp, Norbert; Uhrig, Alexander; Müller-Redetzky, Holger; Nattermann, Jacob; M. Kuebler, Wolfgang; Meisel, Christian; Ralser, Markus; L. Schultze, Joachim; C. Aschenbrenner, Anna; Thibeault, Charlotte; Kurth, Florian; Erik Sander, Leif; Blüthgen, Nils; Sawitzki, Birgit

doi:10.1016/j.cell.2021.12.040

Public

Complement activation induces excessive T cell cytotoxicity in severe COVID-19

Published in Cell • Dec 28, 2021

Authors:

Philipp Georg

Rosario Astaburuaga-García

Lorenzo Bonaguro

Abstract

T cells and plasma levels of complement proteins upstream of C3a were associated with fatal outcome of COVID-19, supporting a pathological role of exacerbated cytotoxicity and complement activation in COVID-19.

Subject

Biology

Immune system

CD16

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