Forsythoside A Mitigates Alzheimer's-like Pathology by Inhibiting Ferroptosis-mediated Neuroinflammation via Nrf2/GPX4 Axis Activation

Wang, Chunyue; Chen, Shanshan; Guo, Hangyu; Jiang, Hongbo; Liu, Honghan; Fu, Haoran; Wang, Di

doi:10.7150/ijbs.69714

Public

Forsythoside A Mitigates Alzheimer's-like Pathology by Inhibiting Ferroptosis-mediated Neuroinflammation via Nrf2/GPX4 Axis Activation

Published in International Journal of Biological Sciences • Jan 1, 2022

Authors:

Chunyue Wang

Shanshan Chen

Hangyu Guo

Abstract

Ferroptosis and neuroinflammation play crucial roles in Alzheimer's disease (AD) pathophysiology. Forsythoside A (FA), the main constituent of Forsythia suspensa (Thunb.) Vahl., possesses anti-inflammatory, antibacterial, antioxidant, and neuroprotective properties. The present study aimed to invest...

Subject

Neuroinflammation

Pharmacology

Lipid peroxidation

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!