Forsythoside A Mitigates Alzheimer's-like Pathology by Inhibiting Ferroptosis-mediated Neuroinflammation via Nrf2/GPX4 Axis Activation

Wang, Chunyue; Chen, Shanshan; Guo, Hangyu; Jiang, Hongbo; Liu, Honghan; Fu, Haoran; Wang, Di

doi:10.7150/ijbs.69714

Public

Forsythoside A Mitigates Alzheimer's-like Pathology by Inhibiting Ferroptosis-mediated Neuroinflammation via Nrf2/GPX4 Axis Activation

Published in International Journal of Biological Sciences • Jan 1, 2022

Authors:

Chunyue Wang

Shanshan Chen

Hangyu Guo

Abstract

-exposed N2a cells. In LPS-stimulated BV2 cells, FA treatment decreased the formation of the pro-inflammatory factors IL-6, IL-1β, and NO. In male APP/PS1 mice, FA treatment ameliorated memory and cognitive impairments and suppressed Aβ deposition and p-tau levels in the brain. Analyses using proteo...

Subject

Neuroinflammation

Pharmacology

Lipid peroxidation

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