MGP promotes CD8<sup>+</sup> T cell exhaustion by activating the NF-κB pathway leading to liver metastasis of colorectal cancer

Rong, Dawei; Sun, Guangshun; Zheng, Zhiying; Liu, Li; Chen, Xiaoyuan; Wu, Fan; Gu, Yichao; Dai, Yongjiu; Zhong, Weizhe; Hao, Xiaopei; Zhang, Chuanyong; Pan, Xiongxiong; Tang, Jinhai; Tang, Weiwei; Wang, Xuehao

doi:10.7150/ijbs.70137

Public

MGP promotes CD8+ T cell exhaustion by activating the NF-κB pathway leading to liver metastasis of colorectal cancer

Published in International Journal of Biological Sciences • Jan 1, 2022

Authors:

Dawei Rong

Guangshun Sun

Zhiying Zheng

Abstract

Matrix Gla protein (MGP) was originally reported as a physiological suppressor of ectopia calcification and has also been reported to be associated with cancer. However, the relation between the biological functions of MGP and the immune response in colorectal cancer (CRC) remains unclear. Here, we ...

Subject

Cancer research

Chromatin immunoprecipitation

Gene knockdown

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