Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis

D. Grotzinger, Andrew; T. Mallard, Travis; A. Akingbuwa, Wonuola; F. Ip, Hill; J. Adams, Mark; M. Lewis, Cathryn; M. McIntosh, Andrew; Grove, Jakob; Dalsgaard, Søren; Lesch, Klaus‐Peter; I. Strom, Nora; Meier, Sandra; Mattheisen, Manuel; D. Børglum, Anders; Mors, Ole; Breen, Gerome; , iPSYCH; Mattheisen, Manuel; Mors, Ole; Meier, Sandra; H. Lee, Phil; S. Kendler, Kenneth; W. Smoller, Jordan; M. Tucker–Drob, Elliot; G. Nivard, Michel

doi:10.1038/s41588-022-01057-4

Public

Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis

Published in Nature Genetics • May 1, 2022

Authors:

Andrew D. Grotzinger

Travis T. Mallard

Wonuola A. Akingbuwa

Abstract

We interrogate the joint genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four broad factors (neurodevelopmental, compulsive, psychotic and internalizing) that underlie genetic correlations among the dis...

Subject

Genetic architecture

Biology

Genetics

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