The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis

Flipo, Marion; Frita, Rosangela; Bourotte, Marilyne; Santos Martínez, Maria; Böesche, Markus; W. Boyle, Gary; Derimanov, Geo; Drewes, Gerard; Gamallo, Pablo; Ghidelli‐Disse, Sonja; Gresham, Stephanie; Jiménez, Elena; de Mercado, Jaime; Pérez‐Herrán, Esther; Porras-De Francisco, Esther; Rullás, Joaquín; Casado, Patricia; Leroux, Florence; Piveteau, Catherine; Kiass, Mehdi; Mathys, Vanessa; Soetaert, Karine; Mégalizzi, Véronique; Tanina, Abdalkarim; Wintjens, René; Antoine, Rudy; Brodin, Priscille; Delorme, Vincent; Moune, Martin; Djaout, Kamel; Slupek, Stéphanie; Kemmer, Christian; Gitzinger, Marc; Ballell, Lluís; Mendoza-Losana, Alfonso; Lociuro, Sergio; Déprez, Benoît; Barros-Aguirre, David; J. Remuiñán, Modesto; Willand, Nicolas; R. Baulard, Alain

doi:10.1126/scitranslmed.aaz6280

Public

The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis

Published in Science Translational Medicine • May 4, 2022

Authors:

Marion Flipo

Rosangela Frita

Marilyne Bourotte

Abstract

The sensitivity of Mycobacterium tuberculosis , the pathogen that causes tuberculosis (TB), to antibiotic prodrugs is dependent on the efficacy of the activation process that transforms the prodrugs into their active antibacterial moieties. Various oxidases of M. tuberculosis have the potential to a...

Subject

Ethionamide

Mycobacterium tuberculosis

Prodrug

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