FTO mediates LINE1 m 6 A demethylation and chromatin regulation in mESCs and mouse development

Wei, Jiangbo; Yu, Xianbin; Yang, Lei; Liu, Xuelian; Gao, Boyang; Huang, Boxian; Dou, Xiaoyang; Liu, Jun; Zou, Zhongyu; Cui, Xiaolong; Zhang, Lisheng; Zhao, Xingsen; Liu, Qinzhe; Cody He, P.; Sepich‐Poore, Caraline; Zhong, Nicole; Liu, Wenqiang; Li, Yanhe; Kou, Xiaochen; Zhao, Yanhong; Wu, You; Cheng, Xuejun; Chen, Chuan; An, Yiming; Dong, Xueyang; Wang, Huanyu; Shu, Qiang; Hao, Ziyang; Duan, Tao; He, Yu‐Ying; Li, Xuekun; Gao, Shaorong; Gao, Yawei; He, Chuan

doi:10.1126/science.abe9582

Public

FTO mediates LINE1 m 6 A demethylation and chromatin regulation in mESCs and mouse development

Published in Science • May 5, 2022

Authors:

Jiangbo Wei

Xianbin Yu

Lei Yang

Abstract

N 6 -methyladenosine (m 6 A) is the most abundant internal modification on mammalian messenger RNA. It is installed by a writer complex and can be reversed by erasers such as the fat mass and obesity-associated protein FTO. Despite extensive research, the primary physiological substrates of FTO in m...

Subject

Demethylation

Chromatin

Cell biology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!