Targeting genome integrity dysfunctions impedes metastatic potency in non–small cell lung cancer circulating tumor cell–derived explants

Tayoun, Tala; Faugeroux, Vincent; Oulhen, Marianne; Déas, Olivier; Michels, Judith; Brullé-Soumaré, Laura; Cairo, Stefano; Scoazec, Jean‐Yves; Marty, Virginie; Aberlenc, Agathe; Planchard, David; Remón, Jordi; Ponce, Santiago; Besse, Benjamin; Kannouche, Patricia; Judde, Jean‐Gabriel; Pawlikowska, Patrycja; Farace, Françoise

doi:10.1172/jci.insight.155804

Public

Targeting genome integrity dysfunctions impedes metastatic potency in non–small cell lung cancer circulating tumor cell–derived explants

Published in JCI Insight • May 5, 2022

Authors:

Tala Tayoun

Vincent Faugeroux

Marianne Oulhen

Abstract

DNA damage and genomic instability contribute to non-small cell lung cancer (NSCLC) etiology and progression. However, their therapeutic exploitation is disappointing. CTC-derived explants (CDX) offer systems for mechanistic investigation of CTC metastatic potency and may provide rationale for biolo...

Subject

Cancer research

Potency

Cell

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