Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

J. Howe, Laurence; G. Nivard, Michel; Morris, Tim; Falkmo Hansen, Ailin; Rasheed, Humaira; Cho, Yoonsu; Chittoor, Geetha; Ahlskog, Rafael; A. Lind, Penelope; Palviainen, Teemu; D. van der Zee, Matthijs; Cheesman, Rosa; Mangino, Massimo; Wang, Yunzhang; Li, Shuai; Klaric, Lucija; M. Ratliff, Scott; F. Bielak, Lawrence; Nygaard, Marianne; Giannelis, Alexandros; A. Willoughby, Emily; A. Reynolds, Chandra; V. Balbona, Jared; A. Andreassen, Ole; Ask, Helga; Baras, Aris; R. Bauer, Christopher; I. Boomsma, Dorret; Campbell, Archie; Campbell, Harry; Chen, Zhengming; Christofidou, Paraskevi; C. Corfield, Elizabeth; C. Dahm, Christina; Dokuru, Deepika; M. Evans, Luke; J. C. de Geus, Eco; Giddaluru, Sudheer; D. Gordon, Scott; Paige Harden, K.; David Hill, W.; Hughes, Amanda; M. Kerr, Shona; Kim, Yongkang; Kweon, Hyeokmoon; Latvala, Antti; A. Lawlor, Debbie; Li, Liming; Lin, Kuang; Magnus, Per; K. E. Magnusson, Patrik; T. Mallard, Travis; Martikainen, Pekka; C. Mills, Melinda; R. Njølstad, Pål; D. Overton, John; L. Pedersen, Nancy; J. Porteous, David; G. Reid, Jeffrey; Silventoinen, Karri; C. Southey, Melissa; Stoltenberg, Camilla; M. Tucker–Drob, Elliot; J. Wright, Margaret; Kweon, Hyeokmoon; Koellinger, Philipp; J. Benjamin, Daniel; Turley, Patrick; J. Howe, Laurence; G. Nivard, Michel; Morris, Tim; Falkmo Hansen, Ailin; Rasheed, Humaira; Cho, Yoonsu; Chittoor, Geetha; Ahlskog, Rafael; A. Lind, Penelope; Palviainen, Teemu; D. van der Zee, Matthijs; Cheesman, Rosa; Mangino, Massimo; Wang, Yunzhang; Li, Shuai; Klaric, Lucija; M. Ratliff, Scott; F. Bielak, Lawrence; Nygaard, Marianne; Giannelis, Alexandros; A. Willoughby, Emily; A. Reynolds, Chandra; V. Balbona, Jared; A. Andreassen, Ole; Ask, Helga; I. Boomsma, Dorret; Campbell, Archie; Campbell, Harry; Chen, Zhengming; Christofidou, Paraskevi; C. Corfield, Elizabeth; C. Dahm, Christina; Dokuru, Deepika; M. Evans, Luke; J. C. de Geus, Eco; Giddaluru, Sudheer; D. Gordon, Scott; Paige Harden, K.; David Hill, W.; Hughes, Amanda; M. Kerr, Shona; Kim, Yongkang; Latvala, Antti; A. Lawlor, Deborah; Li, Liming; Lin, Kuang; Magnus, Per; K. E. Magnusson, Patrik; T. Mallard, Travis; Martikainen, Pekka; C. Mills, Melinda; R. Njølstad, Pål; L. Pedersen, Nancy; J. Porteous, David; Silventoinen, Karri; C. Southey, Melissa; Stoltenberg, Camilla; M. Tucker–Drob, Elliot; J. Wright, Margaret; K. Hewitt, John; C. Keller, Matthew; C. Stallings, Michael; J. Lee, James; Christensen, Kaare; L. R. Kardia, Sharon; A. Peyser, Patricia; A. Smith, Jennifer; F. Wilson, James; L. Hopper, John; Hägg, Sara; D. Spector, Tim; Pingault, Jean‐Baptiste; Plomin, Robert; Havdahl, Alexandra; Bartels, Meike; G. Martin, Nicholas; Oskarsson, Sven; E. Justice, Anne; Y. Millwood, Iona; Hveem, Kristian; Næss, Øyvind; J. Willer, Cristen; Olav Åsvold, Bjørn; Kaprio, Jaakko; E. Medland, Sarah; Walters, Robin; M. Evans, David; Davey Smith, George; Hayward, Caroline; Brumpton, Ben; Hemani, Gibran; M Davies, Neil; K. Hewitt, John; C. Keller, Matthew; C. Stallings, Michael; J. Lee, James; Christensen, Kaare; L. R. Kardia, Sharon; A. Peyser, Patricia; A. Smith, Jennifer; F. Wilson, James; L. Hopper, John; Hägg, Sara; D. Spector, Tim; Pingault, Jean‐Baptiste; Plomin, Robert; Havdahl, Alexandra; Bartels, Meike; G. Martin, Nicholas; Oskarsson, Sven; E. Justice, Anne; Y. Millwood, Iona; Hveem, Kristian; Næss, Øyvind; J. Willer, Cristen; Olav Åsvold, Bjørn; Koellinger, Philipp; Kaprio, Jaakko; E. Medland, Sarah; Walters, Robin; J. Benjamin, Daniel; Turley, Patrick; M. Evans, David; Davey Smith, George; Hayward, Caroline; Brumpton, Ben; Hemani, Gibran; M Davies, Neil

doi:10.1038/s41588-022-01062-7

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Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

Published in Nature Genetics • May 1, 2022

Authors:

Laurence J. Howe

Michel G. Nivard

Tim Morris

Abstract

Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect genetic effects). Family-based GWAS designs can control for demographic and indir...

Subject

Genome-wide association study

Biology

Assortative mating

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