TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

Dornier, Emmanuel; Coumailleau, Franck; Ottavi, Jean‐François; Moretti, Julien; Boucheix, Claude; Mauduit, Philippe; Schweisguth, François; Rubinstein, Eric

doi:10.1083/jcb.201201133

Public

TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

Published in The Journal of Cell Biology • Oct 22, 2012

Authors:

Emmanuel Dornier

Franck Coumailleau

Jean‐François Ottavi

Abstract

The metalloprotease ADAM10/Kuzbanian catalyzes the ligand-dependent ectodomain shedding of Notch receptors and activates Notch. Here, we show that the human tetraspanins of the evolutionary conserved TspanC8 subfamily (Tspan5, Tspan10, Tspan14, Tspan15, Tspan17, and Tspan33) directly interact with A...

Subject

Notch signaling pathway

Notch proteins

ADAM10

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