MALAT1 Is Associated with Poor Response to Oxaliplatin-Based Chemotherapy in Colorectal Cancer Patients and Promotes Chemoresistance through EZH2.

P, Li; X, Zhang; H, Wang; L, Wang; T, Liu; L, Du; Y, Yang; C, Wang

doi:10.1158/1535-7163.mct-16-0591

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MALAT1 Is Associated with Poor Response to Oxaliplatin-Based Chemotherapy in Colorectal Cancer Patients and Promotes Chemoresistance through EZH2.

Shared by NobleBlocks on Jan 9, 2017 • 12:00 AM UTC

Authors:

Li P

Zhang X

Wang H

Abstract

A major reason for oxaliplatin chemoresistance in colorectal cancer is the acquisition of epithelial-mesenchymal transition (EMT) in cancer cells. The long noncoding RNA (lncRNA), MALAT1, is a highly conserved nuclear ncRNA and a key regulator of metastasis development in several cancers. However, i...

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