Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

Wu, Xueling; Zhou, Tongqing; Zhu, Jiang; Zhang, Baoshan; S. Georgiev, Ivelin; Wang, Charlene; Chen, Xuejun; S. Longo, Nancy; K. Louder, Mark; McKee, Krisha; O’Dell, Sijy; P. Perfetto, Stephen; D. Schmidt, Stephen; Shi, Wei; Wu, Lan; Yang, Yongping; Yang, Zhiyong; Yang, Ziying; Zhang, Zhenhai; Bonsignori, Mattia; A. Crump, John; Kapiga, Saidi; E. Sam, Noel; F. Haynes, Barton; Simek, Melissa; R. Burton, Dennis; C. Koff, Wayne; A. Doria‐Rose, Nicole; Connors, Mark; Comparative Sequencing Program, NISC; C. Mullikin, James; J. Nabel, Gary; Roederer, Mario; Shapiro, Lawrence; D. Kwong, Peter; R. Mascola, John

doi:10.1126/science.1207532

Public

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

Published in Science • Aug 12, 2011

Authors:

Xueling Wu

Tongqing Zhou

Jiang Zhu

Abstract

Antibody VRC01 is a human immunoglobulin that neutralizes about 90% of HIV-1 isolates. To understand how such broadly neutralizing antibodies develop, we used x-ray crystallography and 454 pyrosequencing to characterize additional VRC01-like antibodies from HIV-1-infected individuals. Crystal struct...

Subject

Human immunodeficiency virus (HIV)

Virology

Antibody

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!